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For this second edition of a detailed reference for professionals, researchers, and advanced students, Watts (neurology, U. of Alabama-Birmingham) and Koller (movement disorders, Mount Sinai Medical Center) place greater emphasis on the molecular bases of movement disorders, and have added new material reflecting recent research in areas such as genetic abnormalities that can cause familial parkinsonism, major advances in the treatment of Parkinson's disease, and the molecular genetics of inherited ataxias. Material is organized according to clinical patterns of disease expression, with sections on an introduction to movement disorders, neuroscientific foundations, and clinical disorders. Color and b&w medical images are included, and there is a list of patient support organizations.

Table of Contents:

Contributors
Preface
Color Plates
1 Approach to the Patient with a Movement Disorder and Overview of Movement Disorders 3
2 Neurobehavioral Aspects of Movement Disorders 17
3 Neuroimaging of Movement Disorders 35
4 Mitochondria in Movement Disorders 61
5 Functional Anatomy of Basal Ganglia and Motor Systems 87
6 Physiology of the Basal Ganglia and Pathophysiology of Movement Disorders of Basal Ganglia Origin 101
7 Functional Neurochemistry of the Basal Ganglia 113
8 Neurotrophic Factors 131
9 Neuropathology of Movement Disorders: An Overview 143
10 Genetics of Parkinson's Disease and Parkinsonian Disorders 163
11 Epidemiology of Parkinson's Disease 177
12 Neurochemistry and Neuropharmacology of Parkinson's Disease 197
13 Etiology of Parkinson's Disease 209
14 Clinical Manifestations of Parkinson's Disease 233
15 Pharmacologic Treatment of Parkinson's Disease 247
16 Transplantation and Restorative Therapies for Parkinson's Disease 273
17 Stereotaxic Surgery and Deep Brain Stimulation for Parkinson's Disease and Movement Disorders 289
18 Neurobehavioral Abnormalities in Parkinson's Disease 319
19 Parkinson's Disease: Neuropathology 327
20 Progressive Supranuclear Palsy 339
21 Multiple-System Atrophy 359
22 Infectious and Postinfectious Parkinsonism 373
23 Toxin-Induced Parkinsonian Syndromes 383
24 Drug-Induced Parkinsonism 395
25 Rare Degenerative Syndromes Associated with Parkinsonism 403
26 Other Central Nervous System Conditions 421
27 Essential Tremor 431
28 Uncommon Forms of Tremor 459
29 The Pathophysiology of Tremor 481
30 Childhood Dystonia 495
31 Adult-Onset Idiopathic Torsion Dystonias 511
32 Treatment of Dystonia 527
33 Symptomatic Dystonias 541
34 Genetics and Molecular Biology of Huntington's Disease 571
35 Clinical Features and Treatment of Huntington's Disease 589
36 Neuropathology and Pathophysiology of Huntington's Disease 603
37 Tardive Dyskinesia 629
38 Other Choreatic Disorders 639
39 Classification, Clinical Features, and Treatment of Myoclonus 659
40 Pathophysiology of Myoclonic Disorders 671
41 Tourette's Syndrome 685
42 Pathophysiology and Differential Diagnosis of Tics 693
43 The Molecular Genetics of the Ataxias 705
44 Clinical Features and Treatment of Cerebellar Disorders 723
45 Pathophysiology of Cerebellar Disorders 737
46 Corticobasal Degeneration 763
47 Wilson's Disease 779
48 Stiff-Person Syndrome 799
49 Gait Disorders 813
50 Movement Disorders in Childhood 825
51 Movement Disorders and Aging 837
52 Movement Disorders Specific to Sleep and the Nocturnal Manifestations of Waking Movement Disorders 855
53 Psychogenic Movement Disorders 891
54 Systemic Illnesses that Cause Movement Disorders 915
Appendix 927
Index 945