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THE NEW COLOR OF MEDICINE

HUNDREDS OF DIAGRAMS AND CLINICAL PHOTOS INTEGRATED INTO THE TEXT – FOR THE FIRST TIME IN FULL COLOR

A Step Ahead of Everyday Practice — the most authoritative, comprehensive, and useful guide to the entire spectrum of internal medicine… Now in a 16th Edition that fully details the most exciting research and therapeutic advances in decades!

The new 16th Edition of Harrison's. puts at your fingertips unparalleled expert guidance for diagnosing, treating and managing thousands of disorders

Coverage and updates unmatched by any other resource.

With more than 3 million copies of previous editions sold worldwide, Harrison's is unquestionably the best-selling medical book ever. And with good reason. By virtue of its unrivalled comprehensiveness, timeliness, and ease of use… the expertise of its renowned editors and contributors… its invaluable guidelines for ensuring diagnostic accuracy… and its state-of-the-art treatment strategies — Harrison's leads the way.

The 16th Edition improves on a winning formula with:
*State-of-the-art coverage of over 4,700 diseases and disorders—more than any other internal medicine text – in the areas of oncology and hematology; infectious diseases; cardiology; pulmonology; gastroenterology; clinical immunology; rheumatology; endocrinology; and neurology
*A brand new full color format—665 full color drawings, 175 clinical and laboratory images, and hundreds of boxes, tables, and algorithms that use color to guide you to the information you need ASAP in everyday patient care
*Thorough revision and updates of virtually all chapters
*The addition of key new chapters – including extensive new coverage of Critical Care Medicine
*145 algorithms for making accurate clinical decisions fast at the point of care
*1,160 easy-access tables for immediate access to vital information and formulas
*Cardinal manifestations of disease/signs and symptoms in 55 chapters (you'll find yourself turning to this section over and over again). Here you will find all the major manifestations, such as fever, pain, aches and rash, presented in depth, with a referral that takes you to the disease section for the complete chapter

“Learners and practitioners at every level and in virtually every specialty will find it useful….the editors have assembled an impressive array of individual chapter authors…”*

THE 16TH EDITION'S DISTINGUISHED EDITORIAL BOARD: world-recognized authorities in their respective fields

Dennis L. Kasper, M.D.
William Ellery Channing Professor of Medicine
Professor of Microbiology and Molecular Genetics
Harvard Medical School
Director, Channing Laboratory
Department of Medicine
Brigham and Women's Hospital
Boston, Massachusetts

Eugene Braunwald, AB, MD, MA (Hon), MD (Hon), ScD (Hon)
Distinguished Hersey Professor of Medicine
Harvard Medical School
Chairman, TIMI Study Group
Brigham and Women's Hospital
Boston, Massachusetts

Anthony S. Fauci, MD
Chief, Laboratory of Immunoregulation
Director, National Institute of Allergy and Infectious Diseases
National Institutes of Health
Bethesda, MD

Stephen L. Hauser, MD
Betty Anker Fife Professor and Chairman
Department of Neurology
University of California, San Francisco
San Francisco, CA

Dan L. Longo, MD
Scientific Director
National Institute on Aging
National Institutes of Health
Bethesda, MD

J. Larry Jameson, MD
Irving S. Cutter Professor and Chairman
Department of Medicine
Northwestern University Medical School
Physician-in-Chief, Northwestern Memorial Hospital
Chicago, IL

*Online reviews of the previous edition

“I am a dual resident in Emergency medicine and internal medicine. I have studied from many medical texts in my training and its rare that you find a book that teaches you while you read it instead of just facts presented on a page. Harrison's is, in my opinion the root for all medicine board questions, and I would trust no other text for my career in internal medicine.”*

“The bottom line…is that if you are an Internist, you need Harrison's.”*

“[Harrison's] is a must-have for the internist, medical student or anyone who needs in-depth medical information at their fingertips.”*

HERE'S WHAT'S NEW IN THE 16TH EDITION

Harrison's 16th Edition features new, expanded, revised and updated material on the key topics in medical practice today. From the latest research findings to up-to-the-minute advances in diagnostic and treatment methodologies, Harrison's puts the facts you need at your fingertips. Here's just a sample of what you'll find:

CRITICAL CARE
Critical care units — cardiac, general medicine, respiratory, neurological – represent a growing percentage of in-hospital beds. With 10 chapters in three sections, this is a major and timely addition

DISEASE SCREENING AND PREVENTION
You'll find principles and guidelines for screening for common disorders such as cancer, hypertension, lipid disorders, and osteoporosis. These screening approaches should be considered by every internist for routine health maintenance

WOMEN'S HEALTH
An updated overview of practical approaches to the diagnosis and management of disorders and diseases unique to women

SEXUAL DYSFUNCTION
Now addresses management of sexual dysfunction in women as well as men

DISORDERS OF LIPOPROTEIN METABOLISM
Greater focus on the classification, diagnosis, and treatment of disorders of cholesterol and triglyceride metabolism. Features updated treatment guidelines with a focus on the use of statins for reducing cardiovascular risk

ALZHEIMER'S AND RELATED DEMENTIAS
Summarizes the explosion of knowledge in an easily readable style. Presents a clinical guide to the diagnosis of Alzheimer's; how to distinguish Alzheimer's from other dementia problems; and the very latest clinical recommendations on the use of new treatments for dementia

PARKINSON'S DISEASE
Reviews all the new findings in applied and clinical genetics, and provides an authoritative approach to therapeutics including surgical options

MICROBIAL, CHEMICAL, AND RADIATION BIOTERRORISM
The medical profession is on the front line of response to threats of bioterrorism. These chapters were written by recognized experts and edited by Dr. Anthony Fauci who leads the government's biomedical efforts towards national preparedness against such attacks. They are clear and succinct with easily readable charts, tables and algorithms to help you understand the pathogenesis, diagnosis, treatment and prognosis of the diseases in question. No other general medical reference covers all of these important subjects in such a comprehensive and clear manner

HIV/AIDS
This revision of what is widely considered to be the classic treatment of this topic fully reflects the rapid evolution of medical knowledge of HIV disease, particularly the all-important advances in therapeutic strategies. This chapter's clinically practical nature and its comprehensive and analytical approach to the pathogenesis of HIV disease make it a complete reference on HIV/AIDS

IMMUNE SYSTEM
Another truly classic treatment, this chapter has now been updated to include the rapid advances in both basic and clinical immunology. It combines an in-depth description and analysis of the principles of basic immunology with an easy flow into the application of these principles to clinical disease states.

DISORDERS OF IMMUNE-MEDIATED INJURY
Major advances in immunomodulatory therapy realized in rheumatology over the past three years have been captured in extensive revisions in chapters on Rheumatoid Arthritis, Systemic Lupus Erythematosus, and The Spondyloarthropathies

PSEUDOMEMBRANOUS COLITIS due to Clostridium difficile
This important pathogen is a very frequently encountered organism, especially in the hospital setting

STEM CELL AND GENE TRANSFER
Defines different types of stem cells, and discusses potential applications in clinical medicine ranging from bone marrow transplantation to future possibilities such as stem cell transplantation in the heart, pancreatic islets, and central nervous system. There is also a major focus on how gene transfer can be combined with stem cells to modify their function

PERIMENOPAUSE TRANSITION AND HORMONE REPLACEMENT THERAPY
Timely chapter addresses the controversial topic of hormone therapy. Coincides with publication of the results of the Women's Health Initiative, which unexpectedly showed increased cardiovascular risk in women receiving estrogen treatment. Provides practical algorithms for managing the care of women during and after the menopause transition

DISORDERS OF SEXUAL DIFFERENTIATION
Highlights new insights derived from the genetic basis of sex determination

BONE AND MINERAL METABOLISM
Incorporates the vast number of new insights into bone development and turnover. An outstanding review that lays the foundation for understanding the pathophysiology and treatment of various metabolic bone diseases

PLUS – the latest evidence and guidance on the prevention of stroke… new developments in the treatment of multiple sclerosis… vital updates in the fields of neurology and psychiatry… breakthrough advances in the treatment of viral hepatitis… and much more.

Table of Contents:

PART ONE: INTRODUCTION TO CLINICAL MEDICINEPART TWO: CARDINAL MANIFESTATIONS AND PRESENTATION OF DISEASE PART THREE: GENETICS AND DISEASE PART FOUR: NUTRITION PART FIVE: ONCOLOGY AND HEMATOLOGY PART SIX: INFECTIOUS DISEASES PART SEVEN: BIOTERRORISM AND CLINICAL MEDICINE PART EIGHT: DISORDERS OF THE CARDIOVASCULAR SYSTEM PART NINE: DISORDERS OF THE RESPIRATORY SYSTEM PART TEN: CRITICAL CARE MEDICINE PART ELEVEN: DISORDERS OF THE KIDNEY AND URINARY TRACT PART TWELVE: DISORDERS OF THE GASTROINTESTINAL SYSTEM PART THIRTEEN: DISORDERS OF THE IMMUNE SYSTEM, CONNECTIVE TISSUE, AND JOINTS PART FOURTEEN: ENDOCRINOLOGY AND METABOLISM PART FIFTEEN: NEUROLOGIC DISORDERS PART SIXTEEN: POISONING, DRUG OVERDOSE, AND ENVENOMATION