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This manual is a concise, practical, up-to-date book forpractitioners responsible for the care of children with hematologic and oncologic disease. It is specifically designed for medical students, pediatric house staff, fellows in pediatric hematology-oncology seeking a systematic approach to these diseases and a guide in preparation for board examinations, and practicing hematologists and oncologists seeking another opinion and an approach to the diagnosis and management of these disorders. The book is replete with detailed tables, flow diagrams and algorithms for investigation and clinical management of these diseases. The basic orientation and intent of the book is clinical and the book reflects a uniform systematic approach to diagnosis and management of hematologic and oncologic diseases in children.

Table of Contents:

Contributors.Preface to the Third Edition.Preface to the Second Edition.Preface to the First Edition.Classification and Diagnosis of Anemia during Childhood.Anemia during the Neonatal Period.Iron-Deficiency Anemia.Megaloblastic Anemia.Hematologic Manifestations of Systemic Illness.Bone Marrow Failure.Hemolytic Anemia.Polycythemia.Disorders of the White Blood Cells.Disorders of Platelets.Hemostasis.Lymphadenopathy and Splenomegaly.Lympohproliferative Disorders and Myelodysplastic Syndromes.Leukemias.Hodgkin's Disease.Non-Hodgkin's Lymphoma.Central Nervous System Malignancies.Neuroblastoma. Wilms' Tumor.Rhabdomyosarcoma and Other Soft Tissue Sarcomas.Malignant Bone Tumors.Histiocytosis Syndromes.Retinoblastoma.Miscellaneous Tumors.Bone Marrow Transplantation.Supportive Care and Management of Oncologic Emergencies.Late Effects of Childhood Cancer.Appendix 1: Hematologic Reference Values.Appendix 2: CD Antigen Designations.Appendix 3: Biological Tumor Markers.Appendix 4: Pharmacologic Properties of the Commonly Used Chemotherapy Agents.