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This book is a centennial volume celebrating the enormousprogress made in hematology in the 20th century. It is edited by Marshall Lichtman, a distinguished senior hematologist, past president of the American Society of Hematology, and co-editor of the leading text in the field. Hematology is a compendium, with commentaries, of the most important papers published in the field from 1900-1999. The book will be useful for reference—many of the older papers can no longer be found in most libraries, yet are still referred to in current publications, especially review articles—as well as teaching. The editor and a team of associate editors have included the most important papers covering eight categories: anemia; phagocytic cells; platelets; coagulation and thrombosis; lymphocytes and immune disorders; transfusion medicine; hematologic malignancies and therapeutics; and laboratory developments. Each paper is accompanied by a 1-2 page commentary explaining its impact, and references to the developments that resulted.

Table of Contents:

Preface
Acknowledgments
Acknowledgment of Permissions from Publishers and Organizations
Sect. 1 Descriptions of Hematologic Diseases or Syndromes
Chronic Cyanosis, with Polycythemia and Enlarged Spleen: A New Clinical Entity
Ueber paroxysmale Haemoglobinurie [Concerning Paroxysmal Hemoglobinuria]
Pathogene de l'ictere congenital de l'adulte [Pathogenesis of Congenital Jaundice of Adults]
Peculiar Elongated and Sickle-Shaped Red Corpuscles in a Case of Severe Anemia
Hereditare haemorrhagische Thrombasthenie. Ein Beitrag zur Pathologie der Blutplattchen [Hereditary Hemorrhagic Thrombasthenia: A Contribution on the Pathology of Blood Platelets]
Mononuclear Leukocytosis in Reaction to Acute Infections ("Infectious Mononucleosis")
Chronic Arthritis in the Adult, Associated with Splenomegaly and Leucopenia
A Series of Cases of Splenomegaly in Children with Anemia and Peculiar Bone Changes
An Acute Febrile Pleiochromic Anemia with Hyaline Thrombosis of Terminal Arterioles and Capillaries: An Undescribed Disease
Familiare infantile perniziosaartige Anamie (pernizioses Blutbild und Konstitution) [Familial Infantile Pernicious-Like Anemia (Pernicious Blood Picture and Constitution)]
Uber hereditare Pseudohamophilie [On Hereditary Pseudohemophilia]
The Etiology of Primary Granulocytopenia (Agranulocytic Angina)
Tropical Macrocytic Anemia: Its Relation to Pernicious Anaemia
Incipient Myelomatosis or "Essential" Hyperglobulinemia with Fibrinogenopenia: A New Syndrome?
Agammaglobulinemia
Nouvelle anomalie leucocytaire de caractere constitutionnel familial [New Leukocyte Abnormality: Constitutional and Familial]
Splenic Studies. 1. Susceptibility to Infection after Splenectomy Performed in Infancy
Preleukemic Acute Human Leukemia
Histiocytosis X: Integration of Eosinophilic Granuloma of Bone, Letterer-Siwe Disease and Schuller-Christian Disease as Related Manifestations of a Single Nosologic Entity
A Fatal Granulomatosis of Childhood: The Clinical Study of a New Syndrome
Leukemic Reticuloendotheliosis
A Sarcoma Involving the Jaws in African Children
Experimental Nutritional Folate Deficiency in Man
Inherited Antithrombin Deficiency Causing Thrombophilia
An Inherited Abnormality of Neutrophil Adhesion
Resistance to Activated Protein C as a Basis for Venous Thrombosis
Sect. 2 Insights Into the Pathophysiology of Hematologic Disorders
Observations of the Etiologic Relationship of Achylia Gastrica to Pernicious Anemia: The Effect of Administration to Patients with Pernicious Anemia of the Contents of Normal Human Stomach after Ingestion of Beef Muscle
Chronic Hemolytic Anemia with Paroxysmal Nocturnal Hemoglobinuria. A Study of the Mechanism of Hemolysis in Relation to Acid-Base Equilibrium
Absorption and Excretion of Iron
The Role of Isoimmunization in the Pathogenesis of Erythroblastosis Fetalis
Haemolytic Icterus (Acholuric Jaundice) Congenital and Acquired
Sickle Cell Anemia, a Molecular Disease
Studies on the Mechanism of Erythropoietic Stimulation in Parabiotic Rats during Hypoxia
Demonstration of a Thrombocytopenic Factor in the Blood of Patients with Thrombocytopenic Purpura
Presence d'une leuco-agglutine dans le serum d'un cas d'agranulocytose chronique [The Presence of a Leuko-Agglutinin in the Serum of a Case of Chronic Agranulocytosis]
Humoral Regulation of Red Cell Production
The Hemolytic Effect of Primaquine. 1. The Localization of the Drug-Induced Hemolytic Defect in Primaquine-Sensitive Individuals
A Minute Chromosome in Human Chronic Granulocytic Leukemia
The Normal Human Female as a Mosaic of X-Chromosome Activity: Studies Using the Gene for G-6-PD-Deficiency as a Marker
Waterfall Sequence for Intrinsic Blood Clotting
An Enzyme Cascade in the Blood Clotting Mechanism, and Its Function as a Biochemical Amplifier
A New Consistent Abnormality in Chronic Myelogenous Leukemia Identified by Quinacrine Fluorescence and Giemsa Staining
Clinical Importance of Lymphoblasts with T Markers in Childhood Acute Leukemia
Detection of Isolation of Type C Retrovirus Particles from Fresh and Cultured Lymphocytes of a Patient with Cutaneous T-Cell Lymphoma
Helicobacter Pylori-Associated Gastritis and Primary B-Cell Gastric Lymphoma
Sect. 3 Advances in Treatment of hematologic Disease
A New and Greatly Simplified Method of Blood Transfusion
Treatment of Pernicious Anemia by a Special Diet
Hemophilia: Some Properties of Substance Obtained from Normal Human Plasma Effective in Accelerating Coagulation of Hemophilic Blood
A Preparation from Spoiled Sweet Clover (3,3'-Methylene-Bis-(4-Hydroxycoumarin))
Nitrogen Mustard Therapy: The Use of Methyl-Bis([beta]-Chlorethyl) Amine Hydrochloride and Tris ([beta]-Chlorethyl) Amine Hydrochloride for Hodgkin's Disease, Lymphosarcoma, Leukemia and Certain Allied and Miscellaneous Disorders
Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist 4-Aminopteroyl-Glutamic Acid (Aminopterin)
ACTH- and Cortisone-Induced Regressions of Lymphoid Tumors in Man. A Preliminary Report
Erythroblastosis Fetalis. VII. Treatment with Exchange Transfusion
The Treatment of Patients Suffering from Early Myocardial Infarction with Massive and Prolonged Streptokinase Therapy
The Radical Radiotherapy of Regionally Localized Hodgkin's Disease
Quadruple Combination Therapy (VAMP) for Acute Lymphocytic Leukemia of Childhood
Prevention of Rh Immunization
Impaired Platelet-Connective Tissue Reaction in Man after Aspirin Ingestion
Immunological Reconstitution of Sex-Linked Lymphopenic Deficiency
Combination Chemotherapy in the Treatment of Advanced Hodgkin's Disease
Central Nervous System Therapy and Combination Chemotherapy of Childhood Lymphocytic Leukemia
Cytosine Arabinoside and Daunorubicin Therapy in Acute Nonlymphocytic Leukemia
Treatment of Aplastic Anaemia by Antilymphocyte Globulin with and without Allogenic Bone-Marrow Infusions
One Hundred Patients with Acute Leukemia Treated by Chemotherapy, Total Body Irradiation, and Allogeneic Bone Marrow Transplantation
Antileukemic Effect of Chronic Graft Versus Host Disease
Alpha Interferon for Induction of Remission in Hairy Cell Leukemia
Use of All - Trans Retinoic Acid in the Treatment of Acute Promyelocytic Leukemia
Use of Monoclonal Antibody Directed against the Platelet Glycoprotein Ilb/Illa Receptor in High-Risk Coronary Angioplasty
Sect. 4 Diagnostic or Clinical Laboratory Innovations
Uber Agglutinationserscheinungen normalen menschlichen Blutes [On the Agglutination of Normal Human Blood]
The Relation of Blood Platelets to Hemorrhagic Disease: Description of a Method for Determining the Bleeding Time and the Coagulation Time and Report of Three Cases of Hemorrhagic Disease Relieved by Transfusion
The Determination of the Length of Life of Transfused Blood Corpuscles in Man
Reticulosis-Increased Percentage in the Peripheral Blood
Die intravitale Untersuchungsmethodik des Knochenmarks [The Intravital Research Methodology of the Marrow of a Bone]
Anemia: Classification and Treatment on the Basis of Difference in the Average Volume and Hemoglobin Content of Red Corpuscles
A Study of the Coagulation Defect in Hemophilia and in Jaundice
A New Test for the Detection of Weak and "Incomplete" Rh Agglutinins
Morphology and Enumeration of Human Blood Platelets
Effect of Antihemophilic Factor on One-Stage Clotting Tests: A Presumptive Test for Hemophilia and Simple One-Stage Antihemophilic Factor Assay Procedures
High Speed Automatic Blood Cell Counter and Cell Size Analyzer
Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
Aggregation of Blood Platelets by Adenosine Diphosphate and Its Reversal
The Chemotactic Effect of Mixtures of Antibody and Antigen on Polymorphonuclear Leukocytes
Separation and Collection of Leukocytes
The Cloning of Normal "Mast" Cells in Tissue Cultures
The Growth of Mouse Bone Marrow Cells in vitro
Detection of the Sickle Gene in the Human Fetus: Potential for Intrauterine Diagnosis of Sickle Cell Anemia
Appendix