Airways and Vascular Remodelling in Asthma and Cardiovascular Disease: Implications for Therapeutic Intervention

Author: Clive Page
Published: August 1994
Publisher: Elsevier Science & Technology Books
ISBN: 0125435401
Hardcover Book
Number of Pages: 189

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Vascular diseases and asthma are two common diseases associated with considerable morbidity and mortality. Both are chronic, each has an inflammatory component, both are accompanied by remodelling of hollow tubes and both are amenable to early intervention. Those working in the area of cardiovascular diseases have already made significant advances in terms of understanding the pathophysiology and the need to conduct large scale multicentre trials to address simple but pivotal questions about altering outcomes. Those who work in the respiratory field have perhaps lagged behind. This book brings together basic scientists and clinicians from both research fields to compare and contrast the research progress made in each area, and see what lessons can thus be learned.

Table of Contents:

1 Structural Changes in Asthma 3
2 Changes in Vascular Reactivity in Atherogenesis: Markers of Endothelial Cell Dysfunction Associated with Initiation of the Disease 21
3 Vascular Smooth Muscle in Culture and its Relevance to the Study of Atherogenesis 27
4 In vivo Investigations of Vascular Smooth Muscle Remodelling 39
5 Heparin/Heparan Sulphate Regulation of Vascular Smooth Muscle Cell Behaviour 45
6 Regulation of Cytoplasmic Calcium in Airway Smooth Muscle Cells: Implication for Growth and Contractility 71
7 Animal Studies with Drugs Affecting Smooth Muscle Thickening 79
8 Mechanical Consequences of Remodelling of the Airway Wall 91
9 Is Asthma a Reversible Disease? 105
10 Anti-inflammatory Therapy of Asthma: Corticosteroids 115
11 Anti-inflammatory Therapy of Asthma: Non-steroidal Disease Modifying Agents 125
12 Design of Large Multicentre Therapeutic Trials: the Relevance of the Cardiovascular Experience to the Design of Long-term Anti-Asthma Trials 135
13 Discussion Section 151
14 Index 185

Click to compare book prices for Airways and Vascular Remodelling in Asthma and Cardiovascular Disease: Implications for Therapeutic Intervention Airways and Vascular Remodelling in Asthma and Cardiovascular Disease: Implications for Therapeutic Intervention

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