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Dynamics of Bone and Cartilage Metabolism; Volume II

Author: Markus J. Seibel
Published: July 1999
Publisher: Elsevier Science & Technology Books
ISBN: 0126348405
Hardcover Book
Number of Pages: 672
 
Click to compare book prices for Dynamics of Bone and Cartilage Metabolism; Volume II
Dynamics of Bone and Cartilage Metabolism; Volume II


Dynamics of Bone and Cartilage Metabolism is a comprehensive treatise that spans the complete range from basic biochemistry of bone and
cartilage components to the clinical evaluation of disease markers in bone and joint disorders.

Part I of the book provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components, including the important regulators such as cytokines, growth factors, and proteases. The second part of the book covers the organizational structure and cellular metabolism of bone and cartilage. As with the first part, there are separate sections on bone and cartilage addressing their specific and unique functions. For bone, questions on mineralization, remodeling and hormonal regulation are covered as well as the derivation of products of metabolism: for cartilage, the physiology and pathology are reviewed in relation to the products of metabolism, together with recent data from animal and in vitro models. The first two parts of the book serve to contextualize all of the biochemical markers for assessing bone and cartilage metabolism. Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease, both in experimental and clinical settings. A wide range of disorders affecting bone and cartilage metabolism is covered, including different forms of osteoporosis, metastatic bone disease and arthritic diseases, as well as some of the less common growth and degenerative abnormalities. This application-oriented part of the book is complemented by an initial section detailing the methodological and technical aspects of the various biochemical and genetic markers of disease and their measurements.

With contributions from over 75 international experts, this book will be indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of the patient with bone and cartilage diseases.

Key Features:
* Comprehensive and complete guide to bone and cartilage biochemistry and metabolism
* Covers both aspects of skeletal integrity, bone and cartilage
* Spans the interests of both research and clinical disciplines
* Authoritative accounts from more than 75 experts in their respective fields
* Provides clear biochemical bases for disease markers
* Provides state-of-the-art accounts on genetic markers of bone and joint disease
* Provides objective evaluations of the clinical applicability of disease
markers


Table of Contents:

Structure and Biosynthesis of Collagens.
K. von der Mark
Fibrillogenesis and Maturation of Collagens.
S.P. Robins
Vitamin K Dependent Proteins of Bone and Cartilage.
C.M. Gundberg and K. Nishimoto
Non-Collagenous Proteins: Glycoproteins and Related Molecules.
D. Heinegard, T. Saxne, and P. Lorenzo
Proteoglycans and Glycosaminoglycans.
T.E. Hardingham
Regulatory Components: Growth Factors.
G. Russell and P. Croucher
Cytokines and Prostaglandins.
L. Raisz and J. Lorenzo
Integrins and Adhesion Molecules.
M.H. Helfrich and M.A. Horton
Acid and Alkaline Phosphatases.
P. Henthorn, P. Leboy, and J.L. Millán
Matrix Proteases.
I.M. Clark and G. Murphy
Mineralization, Structure, and Function of Bone.
A.L. Boskey
The Cells of Bone.
J.B. Lian and G. Stein
Parathyroid Hormone.
L.A. Fitzpatrick and J.P. Bilezikian
Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: PTHrP: Of Molecules, Mice, and Men.
D. Goltzman and A.C. Karaplis
Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Vitamin D.
R. Bouillon
Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage:
Sex and Steroid Effects on Bone Metabolism.
S. Khosla and B.L. Riggs
Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Physiology of Calcium and Phosphate Homeostasis
R. Rizzoli and J.-P. Bonjour
Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage:
New Concepts in Bone Remodeling.
D.W. Dempster
Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Products of Bone Collagen Metabolism.
J. Risteli and L. Risteli
Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Supramolecular Structure of Cartilage Matrix.
P. Bruckner and E.F. Eikenberry
Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Physiology and Pathology of Cartilage Metabolism.
M.T. Bayliss
Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Products of Cartilage Metabolism.
D.-H. Manicourt
Fluid Dynamics of the Joint Space Trafficking of Matrix Breakdown Products.
P.A. Simkin
In Vitro Models of Cartilage Metabolism.
H.J. Häuselmann
Animal Models of Cartilage Breakdown.
R.D. Altman and C.J. Lozada
Genetic Approaches to Metabolic Bone Disease.
H.A.P. Pols, J.P.T.M. van Leeuwen, and A.G. Uitterlinden
Measurement of Local and Systemic Regulators of Bone Metabolism.
H. Schmidt-Gayk
Measurement of Biochemical Markers of Bone Formation.
R. Eastell and K.E. Naylor
Measurement of Biochemical Markers of Bone Resorption.
M.E. Kraenzlin and M.J. Seibel
Validation of Local and Systematic Markers of Bone Turnover.
E.F. Eriksen and K. Brixen
Genetic Markers of Joint Disease.
S. Gay, M. Neidhart, and R.E. Gay
Markers of Cartilage Metabolism.
E.J. Thonar, M.E. Lenz, K. Masuda, and D.-H. Manicourt
Postmenopausal Osteoporosis.
P.J. Delmas and P. Garnero
Age-Related Osteoporosis.
C. Rosen
Osteoporosis in Men.
E.S. Orwoll
Steroid Induced Osteoporosis.
I.R. Reid
Secondary Osteoporosis.
E. Shane
Osteomalacia and Rickets.
M.K. Drezner
Renal Osteodystrophy.
K.J. Martin and E.A. Gonzalez
Primary Hyperparathyroidism.
S.J. Silverberg and J.P. Bilezikian
Paget's Disease of Bone.
A. Grauer and E.S. Siris
Metastatic Bone Disease.
J.-J. Body
Rare Bone Diseases.
M.P. Whyte
Rheumatoid Arthritis and Other Inflammatory Joint Pathologies.
S.R. Goldring and M.B. Goldring
Osteoarthritis and Degenerative Spine Pathologies.
K. Akesson
Normal and Abnormal Growth and Development.
J.M. Gertner


Click to compare book prices for Dynamics of Bone and Cartilage Metabolism; Volume II
Dynamics of Bone and Cartilage Metabolism; Volume II





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