From NEUROSCIENCE To NEUROLOGY: Neuroscience, Molecular Medicine, and the Therapeutic Transformation of Neurology

Author: Stephen Waxman
Published: October 2004
Publisher: Elsevier Science & Technology
ISBN: 0127389032
Hardcover Book
Number of Pages: 544

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Neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty offering new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson's disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments, and ultimately cures, for currently untreatable disorders of the brain and spinal cord.

Table of Contents
Preface vii
Contributors ix
I Clinical Rewards From Neuroscience, Molecular Medicine, and Translational Research
1 Seeing the Brain So We Can Save It: The Evolution of Magnetic Resonance Imaging as a Clinical Tool 3
2 Advances in the Acute Treatment and Secondary Prevention of Stroke 21
3 Preserving Function in Acute Nervous System Injury 35
4 Slowing the Progression of Multiple Sclerosis 61
5 The Emergence of Neurosurgical Approaches to the Treatment of Epilepsy 81
6 The Neurobiology of Migraine and Transformation of Headache Therapy 107
7 Botulinum Toxins: Transformation of a Toxin into a Treatment 125
8 Prospects for Slowing the Progression of Parkinson's Disease 141
9 Current Neurosurgical Treatments for Parkinson's Disease: Where Did They Come From? 159
10 Treatable Peripheral Neuropathies: Plasma Exchange, Intravenous Immunoglobulin, and Other Emerging Therapies 175
11 Molecular Pharmacology and the Treatment of Tourette's Syndrome and Attention Deficit-Hyperactivity Disorder 183
12 Neuroscience, Molecular Medicine, and New Approaches to the Treatment of Depression and Anxiety 193
II Moving Toward The Clinic: Evolving Themes and Technologies
13 Genomics, Proteomics, and Neurology 217
14 Neuroprotection: Where Are We Going? 237
15 Prospects for Gene Therapy for Central Nervous System Disease 267
16 Therapeutics Development for Hereditary Neurological Diseases 285
17 Inherited Channelopathies of the CNS: Lessons for Clinical Neurology 293
18 Inherited Channelopathies of Muscle: Implications for Therapy 303
19 Transcriptional Channelopathies of the Nervous System: New Targets for Molecular Medicine 319
20 New Molecular Targets for the Treatment of Neuropathic Pain 339
21 Therapeutic Transfer and Regeneration of Neural Progenitors or Neurons in Gray Matter of the Adult Brain 357
22 Cellular Plasticity of the Adult Human Brain 375
23 Harnessing Endogenous Stem Cells for Central Nervous System Repair 387
24 Neuropathies-Translating Causes into Treatments 405
25 Therapeutic Potential of Neurotrophic Factors 419
26 Promoting the Regeneration of Axons within the Central Nervous System 433
27 Alzheimer's Disease: Clinical Features, Neuropathological and Biochemical Abnormalities, Genetics, Models, and Experimental Therapeutics 445
28 Behavioral Intervention and Recovery from CNS Damage 459
29 What Functional Brain Imaging Will Mean for Neurology 471
Index 493

Click to compare book prices for From NEUROSCIENCE To NEUROLOGY: Neuroscience, Molecular Medicine, and the Therapeutic Transformation of Neurology From NEUROSCIENCE To NEUROLOGY: Neuroscience, Molecular Medicine, and the Therapeutic Transformation of Neurology

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