AIDS and Other Manifestations of HIV Infection

Author: Gary P. Wormser
Published: May 2004
Publisher: Academic Press, Incorporated
ISBN: 0127640517
Hardcover Book
Number of Pages: 1000

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Extensively revised and updated, the new edition of AIDS and Other Manifestations of HIV Infection is an essential reference resource providing a comprehensive overview of the biologic properties of the etiologic viral agent, its clinicopathological manifestations, the epidemiology of its infection, and present and future therapeutic and preventive options.

Key Features:
·Provides in depth discussions of particular clinical issues on a system-by-system basis for the major systems involved
·Chronicles the emerging story of HIV infection and describes the science behind its diverse manifestations and consequences

New to this Edition:
·Expanded section on clinical manifestations includes new chapters on cardiovascular, renal and dermatologic manifestations of HIV infection
·Additional chapters on molecular diagnostic techniques, the role of host genetic variation in HIV infection and its manifestations, the discovery and development of new HIV medicines, analysis of HIV dynamics using mathematical models, toxicities of antiretroviral therapy, HIV drug susceptibility testing, practical therapeutics and the global impact of HIV and AIDS.

This book will be invaluable for anyone currently working or about to start work in HIV medicine including virologists, immunologists, infectious disease physicians, other health care providers and public health specialists. A comprehensive overview of the biologic properties of the etiologic viral agent, its clinico-pathological manifestations, the epidemiology of its infection, and present and future therapeutic and preventive options, revised (first edition, 1987) in accordance with a vast amount of new knowledge. New chapters have been added on viral cofactors in the pathogenesis of HIV disease; virologic and biologic features of HIV-2; simian retroviruses; care of the adult patient with HIV infection; ophthalmologic aspects of HIV infection; gastrointestinal manifestations of AIDS; occupational issues related to the HIV epidemic; oral lesions associated with HIV infection; immunizations, vaccine-preventable diseases, and HIV infection; and AIDS and the ethics of prevention, research, and care.

Table of Contents
List of Contributors
Preface
Acknowledgments
Dedication
1 The Epidemiology of HIV and AIDS 3
2 Epidemiology of Pediatric HIV Infection 31
3 The Genetic Diversity and Global Molecular Epidemiology of HIV 43
4 Introduction to Retroviruses 57
5 The Neuropathogenesis of HIV-1 Infection 95
6 Viral Cofactors in the Immune Pathogenesis and Clinical Manifestations of HIV Infection 117
7 Virologic and Biologic Features of Human Immunodeficiency Virus Type 2 (HIV-2) 131
8 Laboratory Detection of Human Retroviral Infection 147
9 Molecular Diagnostic Techniques and Other Tests for Direct Detection of HIV 185
10 Simian Retroviruses 195
11 Immunodeficiency in HIV-1 Infection 265
12 The Role of Host Genetic Variation in HIV Infection and its Manifestations 285
13 Care of the Adult Patient with HIV Infection 305
14 HIV Disease in Women 371
15 HIV Infection in Children 389
16 Pulmonary Complications of HIV Infection 407
17 Mycobacterial Disease in Patients with HIV Infection 423
18 Neurologic Complications of HIV and AIDS 479
19 AIDS Psychiatry: Psychiatric and Palliative Care, and Pain Management 537
20 The Gastrointestinal and Hepatobiliary Systems in HIV Infection 577
21 Neoplastic Complications of HIV Infection 597
22 Hematologic Manifestations of HIV Infection 613
23 Cardiac Manifestations in Human Immunodeficiency Virus Infection 635
24 Renal Manifestations of HIV infection 651
25 Skin Manifestations of HIV Infection 663
26 Ophthalmologic Aspects of HIV Infection 697
27 General Pathology of HIV Infection 733
28 Neuropathology of AIDS 773
29 Infection Control Considerations to Prevent HIV Transmission in Healthcare Settings 803
30 HIV Era Occupational Exposures and Risks 811
31 Antiretroviral Chemotherapy 841
32 Discovery and Development of New HIV Medicines 855
33 Toxicities of Antiretroviral Therapy 867
34 HIV Drug Susceptibility Testing 883
35 The Analysis of HIV Dynamics Using Mathematical Models 905
36 Practical Therapeutics 913
37 Immune-based Therapies for HIV Infection 931
38 Immunization, Vaccine-preventable Diseases, and HIV Infection 947
39 Progress in the Development and Testing of HIV Vaccines 973
40 The Public Health Response to the HIV Epidemic in the U.S. 997
41 The Global Impact of HIV and AIDS 1013
42 Nursing Perspectives in the Care of Persons with HIV Infection 1029
43 Ethical Challenges of the Global AIDS Epidemic 1045
Index 1055

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