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List of contributors
1 Principles of molecular biology as applied to the study of disease 3
2 In vitro models in the study of renal cystogenesis 39
3 Mouse models of polycystic kidney disease 63
4 In vivo models of PKD in non-murine species 88
5 Pathogenesis of polycystic kidney disease: basement membrane and extracellular matrix 111
6 Pathogenesis of polycystic kidney disease: altered cellular function 125
7 Classification of cystic kidneys 167
8 Diagnostic imaging of renal cystic diseases 189
9 Autosomal recessive polycystic kidney disease: clinical and genetic profiles 237
10 Acquired renal cystic disease 267
11 Tuberous sclerosis complex 283
12 Von Hippel-Lindau Disease 309
13 Definition and natural history of autosomal dominant polycystic kidney disease 333
14 Cloning strategies and genetics of type 1 autosomal dominant polycystic kidney disease 356
15 Genetic heterogeneity of autosomal dominant polycystic kidney disease 391
16 Hypertension in polycystic kidney disease 407
17 Progression to renal insufficiency 430
18 Management of end-stage renal failure and problems of transplantation in autosomal dominant polycystic kidney disease 450
19 Chronic pain and its medical and surgical management in renal cystic diseases 462
20 Miscellaneous renal and systematic complications of autosomal dominant polycystic kidney disease including infection 483
21 Polycystic liver disease 500
22 Intracranial aneurysms in autosomal dominant polycystic kidney disease 530
23 Particular problems in childhood and adolescence in autosomal dominant polycystic kidney disease 548
24 Counselling and ethical considerations in autosomal dominant polycystic kidney disease 568
Index 584