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List of Contributors
Abbreviations
Introduction
Pt. I General aspects of bone turnover and growth
1 New aspects of bone biology 3
Pt. II Normal parathyroid function and PTH action
2 Regulation of PTH secretion and synthesis and of parathyroid cell proliferation 25
3 Roles of parathyroid hormone-related peptide and the PTH/PTHrP receptor in skeletal development: implications for growth in children with end-stage renal disease 53
Pt. III Pathogenesis of secondary uremic hyperparathyroidism
4 Abnormal PTH synthesis, secretion, and metabolism; pathological parathyroid cell growth and apoptosis in chronic renal failure 69
5 Parathyroid gland function in patients with renal failure 111
Pt. IV Vitamin D metabolism and action in chronic renal failure
6 Vitamin D metabolism and action in chronic renal failure 135
Pt. V Pathogenetic and clinical aspects of renal bone disease
7 Cytokines and growth factors in renal bone disease 159
8 Osteitis fibrosa, osteomalacia, and mixed bone lesions 185
9 Adynamic bone disease in uremia 227
10 Osteoporosis in uremia 269
11 Dialysis-associated amyloidosis 285
12 Bone diseases in children with chronic renal failure 309
Pt. VI Soft tissue calcification in chronic renal failure
13 Soft tissue calcification in chronic renal failure 345
Pt. VII Non-invasive and invasive diagnosis of renal blood disease
14 Classical serum biochemistry and new biochemical markers 379
15 X-ray, US, CT, and MR imaging of skeleton and joints 397
16 Imaging and intervention of parathyroid hyperplasia 421
17 The use of bone histomorphometry in renal osteodystrophy 439
Pt. VIII Prophylaxis and treatment of renal osteodystrophy
18 Medical therapy in pre-dialysis chronic renal failure 453
19 Medical therapy in dialysis patients 473
20 Management in renal transplant recipients 491
21 New vitamin D analogs and calcimmetics 513
22 Surgical management 537
Index 555