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Contributors I INTRODUCTION 1. Basic Concepts and the Functional Organization of the Immune System, 3 II PHYLOGENY OF THE IMMUNE SYSTEM 2. Development of Primitive Recognition Systems in Invertebrates, 33 3. Ontogeny and Phylogeny of MHC-like Molecules, 53 4. Early Development of the Immunoglobulin Gene Superfamily, 85 5. Evolutionary Origins of Immunoglobulin Genes, 108 6. Organization and Assembly of Immunoglobulin Genes, 129 7. Developmental Control of T-Cell Antigen Receptor Gene Rearrangement and III ONTOGENY OF THE IMMUNE SYSTEM 8. Stem Cells, 177 9. Monocytes, Macrophages, and Accessory Cells, 198 10. T-Cell Development and Repertoire Selection, 217 11. B Lymphocyte Generation as a Developmental Process, 238 IV MOLECULAR ASPECTS OF RECOGNITION 12. Functional and Molecular Aspects of Antigen Processing 13. Ontogeny and Phylogeny of Complement, 290 14. Origin and Function of Cytokines involved in the Development of Immune 15. Functional and Molecular Aspects of T-Cell Activation, 333 16. Activation and Inactivation in Regulation of the B Cell Response, 365 V. DEVELOPMENT OF THE IMMUNE SYSTEM IN HEALTH 17. Immunological Manipulation and Immunopharmacology 18. Immune Surveillance and Natural Immunity, 401 19. The Immunobiology of Aging, 426 20. Development of Normal and Abnormal Immune Functions in Humans, 452 Index, 471
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