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Contributors
1 Historical Notes on Infectious Disease 1
2 Infectious Diseases: An Overview 7
Pt. I Pathophysiology of Infectious Diseases
3 Microbes and Virulence Factors: Bacteria 19
4 Pathophysiology of Viruses and Viral Diseases 27
5 Parasitic Protozoa and Helminths 37
6 Fungi and Fungal Diseases 43
7 Epidemiology in Clinical Infectious Diseases 53
8 Epidemiology and Control of Infectious Diseases in Health Care Facilities 61
9 Host Responses to Infection: Fever, Hyperthermia, and Hypothermia 71
10 The Acute Inflammatory Response 83
11 The Specific Immune Response 91
Pt. II Diagnostic Methods in Infectious Disease
12 Modern Imaging Techniques in Infectious Disease 111
13 Hematologic Alterations in Infectious Disease Patients 121
14 Metabolic and Endocrine Alterations in Infectious Disease Patients 133
15 Specimen Management and Rapid Detection of Infectious Agents 137
16 Clinical Bacteriology 145
17 Clinical Virology 159
18 Clinical Mycology 169
19 Clinical Parasitology 181
20 Rickettsia and Chlamydia 195
Pt. III Antimicrobial Drugs: Principles and Usage
21 Mechanisms of Antimicrobial Action and Resistance 209
22 Pharmacology of Antimicrobials 217
23 Antimicrobial Toxicities and Drug Interactions 225
24 Selection of Antimicrobials for Treatment 233
25 Outpatient Parenteral Therapy of Serious Infections 241
26 Control of Antimicrobial Usage 245
27 Penicillins 249
28 Cephalosporins 257
29 Other Beta-lactam Antibiotics: Penems, Carbapenems, and Monobactams 265
30 Aminoglycosides 273
31 Glycopeptides 285
32 Macrolides and Clindamycin 291
33 Tetracyclines and Chloramphenicol 299
34 Fluoroquinolones 305
35 Sulfonamides and Trimethoprim 313
36 Miscellaneous Antibacterial Drugs 319
37 Antimycobacterial Drugs 327
38 Antimicrobial Therapy for Bacterial Diseases 337
39 Antiviral Drugs and Therapy 349
40 Antiparasitic Drugs and Therapy 365
41 Antifungal Drugs 389
42 Selection of Antifungal Drugs for Deep Mycoses 397
Pt. IV Vaccines and Immunomodulatory Agents
43 Principles of Vaccine Development and Immunoprophylaxis 407
44 Passive Immunoprophylaxis and Treatment 411
45 Specific Vaccines 415
46 Growth Factors, Immunomodulators, and Cytokines 427
Pt. V Infectious Disease Syndromes
47 Approach to the Patient with Fever: Acute Febrile Illness 439
48 Fever in Hospitalized Patients 449
49 Fever of Unknown Origin 459
50 Bacteremia, Sepsis, and Septic Shock 471
51 Infections with Rash 483
52 Cellulitis and Abscesses 501
53 Infectious Diseases with Lymphadenopathy 505
54 Upper Respiratory Tract Infections 513
55 Bronchitis and Bronchiectasis 523
56 Acute Pneumonia 529
57 Cavitary Pulmonary Disease 539
58 Diffuse Pulmonary Infiltrates and Acute Respiratory Distress Syndrome 557
59 Pleurisy and Empyema 565
60 Intraoral Infections 573
61 Diarrhea and Gastroenteritis 581
62 Hepatitis 589
63 Pyogenic Biliary Tract and Hepatic Infections 597
64 Infectious Complications of Pancreatitis 605
65 Peritonitis and Intraabdominal Abscesses 613
66 Infective Endocarditis 621
67 Intravenous Catheter-Related Infections, Suppurative Thrombophlebitis, and Mycotic Aneurysms 637
68 Myocarditis and Pericarditis 643
69 Urinary Tract Infections 649
70 Genital Herpes, Syphilis, and Genital Ulcer Disease 657
71 Urethritis, Epidydimitis, Orchitis, Prostatitis 669
72 Vulvovaginitis, Cervicitis, and Pelvic Inflammatory Disease 681
73 Meningitis 689
74 Encephalitis 703
75 Infections Associated with Myelopathy, Radiculopathy, and Neuropathy 715
76 Focal Central Nervous System Infections 723
77 Ocular and Periocular Infections 733
78 Osteomyelitis 741
79 Infectious and Postinfectious Arthritis 757
80 Myositis and Fasciitis 767
81 Chronic Fatigue Syndrome 773
Pt. VI Infections in Special Patient/Risk Groups
82 Postsurgical Wound Infections 783
83 Burn Infections 789
84 Infections Complicating Traumatic Injury 795
85 Prosthetic Device Infections 801
86 Infection in the Immunodeficient Patient 809
87 Infection in the Organ Transplant Recipient 821
88 Hematopoietic Stem Cell Transplantation 829
89 Infection in the Malnourished Patient 839
90 Intravenous Drug Abuse and Infection 849
91 Alcohol Abuse, Host Defenses, and Infection 853
92 Fever in Travelers to Tropical Countries 859
93 Endemic and Traveler's Diarrhea in Tropical Countries 875
94 Eosinophilia in Travelers to Tropical Countries 881
95 Infections after Animal Bites and Scratches 885
96 Ectoparasite-Related Diseases 891
Pt. VII Human Immunodeficiency Virus and AIDS
97 Epidemiology and Prevention 905
98 AIDS Pathogenesis: Molecular Biology and Virology of HIV 915
99 AIDS Immunology 927
100 Clinical Manifestations of HIV Infection and AIDS 937
101 Antiretroviral Therapy 959
102 Therapy of Opportunistic Infections 965
103 Vaccines 977
Index 981