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Contributors
Pt. I Primary Mediators of the Coping Response
1 Synthesis, Storage, and Secretion of Adrenal Medullary Hormones: Physiology and Pathophysiology 3
2 Sympathetic Nervous System Physiology and Pathophysiology in Coping with the Environment 21
3 Catecholamines in the Brain and Responses to Environmental Challenges 45
4 Actions of Corticotropin on the Adrenal Cortex: Biochemistry and Cell Biology 61
5 Proopiomelanocortin Synthesis and Cell-Specific Processing 85
6 Regulation and Actions of Corticotropic-Releasing Hormone 103
7 Conticotropin-Releasing Factor in Brain: Executive Gating of Neuroendocrine and Functional Outflow 125
Pt. II Fear, Stress, and Coping
8 Coping with Danger: The Neural Basis of Defensive Behavior and Fearful Feelings 139
9 Neurobiology of Interpreting and Responding to Stressful Events: Paradigmatic Role of the Hippocampus 155
10 Chronic Stress and Energy Balance: Role of the Hypothalamo-Pituitary-Adrenal Axis 179
11 Adrenocortical Responses to Stress and their Modulation in Free-Living Vertebrates 211
Pt. III Stress and Coping During the Life Course
12 Development of the Hypothalamic-Pituitary-Adrenal Axis and the Stress Response 237
13 Development of Individual Differences in Behavioral and Endocrine Responses to Stress: Role of the Postnatal Environment 271
14 Mechanisms of Glucocorticoid Actions in Stress and Brain Aging 293
Pt. IV Coping: Impact of Diurnal Rhythms and Sleep
15 Roles of Sleep-Wake and Dark-Light Cycles in the Control of Endocrine, Metabolic, Cardiovascular, and Cognitive Function 313
16 Hormones, Cytokines, and Sleep 331
Pt. V Stress, Coping, and Immune Defenses
17 Regional Neural Regulation of Immunity: Anatomy and Function 353
18 Role of Endogenous Glucocorticoids in Immune System Function: Regulation and Counterregulation 381
19 Interactions between the Hypothalamic-Pituitary-Adrenal Axis and Immune System during Viral Infection: Pathways for Environmental Effects on Disease Expression 425
20 Regulation of Inflammatory Autoimmune Diseases 451
21 Immunophysiology: The Interaction of Hormones, Lymphohemopoietic Cytokines, and the Neuroimmune Axis 469
22 Environmental Factors and Disease: Stress and Cancer 497
Pt. VI Stress, Coping, and the Social Environment
23 Physiological and Pathophysiological Implications of Social Stress in Mammals 517
24 Social Ordering and Health 533
Index 547