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Contributors
1 Epidemiological Principles for the Study of Gastrointestinal Cancers 3
2 Prevention and Screening Principles Relevant to Gastrointestinal Malignancies 9
3 The Role of Inheritance in the Diagnosis and Management of Gastrointestinal Malignancies 37
4 Developmental Biology of the Gastrointestinal Tract 44
5 General Pathobiological Features of Gastrointestinal Neoplasia 69
6 Therapeutic Principles of Gastrointestinal Neoplasia: Surgery 80
7 Therapeutic Principles of Gastrointestinal Neoplasia: Radiation Oncology 88
8 Therapeutic Principles of Gastrointestinal Neoplasia: Chemotherapy 91
9 Therapeutic Principles of Gastrointestinal Neoplasia: Emerging Therapies: Vaccines 102
10 Therapeutic Principles of Gastrointestinal Neoplasia: Emerging Therapies: Gene Therapy 112
11 Therapeutic Principles of Gastrointestinal Neoplasia: Emerging Therapies: Antiangiogenic and Antimetastatic Agents 121
12 Epidemiology and Molecular Epidemiology of Esophageal Cancer 129
13 Molecular Biology of Esophageal Cancer 155
14 Pathology and Natural History of Esophageal Cancer 167
15 Clinical Aspects and Management of Esophageal Carcinoma: Diagnostic and Staging Procedures 182
16 Clinical Aspects and Management of Esophageal Carcinoma: Management Options: Potentially Resectable Esophageal Cancer 190
17 Clinical Aspects and Management of Esophageal Carcinoma: Management Options: Locally Advanced Unresectable Esophageal Cancer 218
18 Clinical Aspects and Management of Metastatic Carcinoma of the Esophagus and Gastroesophageal Junction 227
19 Barrett's Esophagus: Molecular Biology and Pathobiology 231
20 Barrett's Esophagus: Clinical Aspects and Management 241
21 Epidemiology and Molecular Epidemiology of Gastric Cancer 257
22 Molecular Biology of Gastric Cancer 268
23 Pathology and Natural History of Gastric Cancer 281
24 Clinical Aspects and Management of Gastric Carcinoma: Diagnostic and Staging Procedures 294
25 Clinical Aspects and Management of Gastric Carcinoma: Management Options: Potentially Resectable Gastric Cancer 302
26 Locally Advanced Unresectable Gastric Cancer 311
27 Management Options: Metastatic Gastric Carcinoma 316
28 Epidemiology and Molecular Epidemiology of Pancreatic Cancer 329
29 Molecular Biology of Pancreatic Adenocarcinoma 336
30 Pathology and Natural History of Pancreatic Cancer 344
31 Clinical Aspects and Management of Pancreatic Adenocarcinoma: Diagnostic and Staging Procedures 355
32 Clinical Aspects and Management of Pancreatic Adenocarcinoma: Management Options: Potentially Resectable Pancreatic Cancer 363
33 Clinical Aspects and Management of Pancreatic Adenocarcinoma: Management Options: Locally Advanced Unresectable Pancreatic Cancer 377
34 Clinical Aspects and Management of Metastatic Pancreatic Cancer 386
35 Epidemiology, Molecular Epidemiology, and Biomarkers of Biliary Tract Cancers 401
36 Molecular Biology of Cholangiocarcinoma and Gallbladder Carcinoma 413
37 Pathology and Natural History of Cholangiocarcinoma and Gallbladder Carcinoma 420
38 Clinical Aspects and Management of Cholangiocarcinoma and Gallbladder Carcinoma: Diagnostic and Staging Procedures 428
39 Clinical Aspects and Management of Cholangiocarcinoma and Gallbladder Carcinoma: Potentially Resectable Gallbladder Carcinoma or Cholangiocarcinoma 436
40 Clinical Aspects and Management of Cholangiocarcinoma and Gallbladder Carcinoma: Management Options: Unresectable Gallbladder Carcinoma and Cholangiocarcinoma 454
41 Epidemiology and Molecular Epidemiology of Hepatocellular Cancer 463
42 Molecular Biology of Hepatocellular Cancer 471
43 Pathology and Natural History of Hepatocellular Carcinoma 507
44 Clinical Aspects and Management of Hepatocellular Cancer: Diagnostic and Staging Procedures 515
45 Clinical Aspects and Management of Hepatocellular Cancer: Management Options: Potentially Resectable Hepatocellular Carcinoma 522
46 Clinical Aspects and Management of Hepatocellular Cancer: Management Options: Metastatic Hepatocellular Carcinoma 529
47 Epidemiology, Molecular Epidemiology, and Molecular Biology of Small Bowel and Appendiceal Adenocarcinomas 539
48 Pathology and Natural History of Small Bowel and Appendiceal Cancers 549
49 Clinical Aspects and Management of Small Bowel and Appendiceal Cancers: Diagnostic and Staging Procedures 560
50 Clinical Aspects and Management of Small Bowel and Appendiceal Cancers: Management Options: Potentially Resectable Small Bowel and Appendiceal Carcinomas 569
51 Clinical Aspects and Management of Small Bowel and Appendiceal Cancers: Management Options: Unresectable, Locally Advanced, and Metastatic Small Bowel and Appendiceal Carcinomas 585
52 Epidemiology and Prevention of Colorectal Cancer 593
53 Molecular Biology of Colorectal Cancer 635
54 Familial Colorectal Cancer Syndromes 645
55 Pathology and Natural History of Colorectal Cancer 665
56 Clinical Aspects and Management of Colon Adenocarcinoma: Diagnostic and Staging Procedures 676
57 Clinical Aspects and Management of Colon Adenocarcinoma: Management of Local and Locoregional Colon Cancer 682
58 Clinical Aspects and Management of Rectal Adenocarcinoma: Diagnostic and Staging Procedures 694
59 Clinical Aspects and Management of Rectal Adenocarcinoma: Management Options: Resectable Rectal Carcinoma 702
60 Clinical Aspects and Management of Rectal Adenocarcinoma: Management Options: Unresectable Rectal Carcinoma 714
61 Management Options: Metastatic Colorectal Carcinoma 728
62 Pathology, Molecular Biology, and Natural History of Anal Cancer 749
63 Clinical Aspects and Management of Anal Cancer 760
64 Management of Neuroendocrine Cancers of the Gastrointestinal Tract: Carcinoid Tumors 773
65 Management of Neuroendocrine Cancers of the Gastrointestinal Tract: Islet Cell Carcinoma of the Pancreas and Other Neuroendocrine Carcinomas 780
66 Mucosa-Associated Lymphoid Tissue Lymphomas 803
67 Low- and High-Grade Lymphomas 812
68 Epidemiology, Pathology, Molecular Biology, and Natural History of Gastrointestinal Sarcomas 821
69 Clinical Aspects and Management of Gastrointestinal Sarcomas: Management Options: Potentially Resectable Gastrointestinal Sarcomas 826
70 Clinical Aspects and Management of Gastrointestinal Sarcomas: Management Options: Unresectable or Metastatic Gastrointestinal Sarcomas 834
71 Nutritional Support of Patients with Gastrointestinal Malignancies 841
72 Management of Obstructive Complications of Upper Gastrointestinal Tract: Esophagus, Stomach, and Biliary Tree 866
73 Management of Obstructive Complications of Lower Gastrointestinal Tract: Colon and Rectum 875
74 Pain Management 881
Index 893