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List of contributors
Pt. I, Sect. 1 Anatomy, epidemiology, and pathology
1 Historical perspective: past, present, and future 3
2 Renal and adrenal anatomy 17
3 Diagnosis and management of the incidental renal mass 31
4 Epithelial tumors of the kidney 40
5 Paraneoplastic manifestations of renal cell carcinoma 55
6 Staging of renal cell carcinoma 61
7 Tumor markers 66
8 Renal cell carcinoma in dialysis and transplantation 74
Pt. I, Sect. 2 Renal cell carcinoma: molecular genetics and immunobiology
9 Basic biology and clinical behavior of renal cell carcinoma 81
10 Molecular cytogenetics of renal cell tumors 90
11 Hereditary renal cell carcinoma and the von Hippel-Lindau gene 98
12 Antigens recognized by T lymphocytes on renal cell carcinoma 111
13 Monoclonal antibodies to renal cancer antigens 118
14 Tumor vaccines 126
15 New approaches for biological therapy of kidney tumors: preclinical models and perspectives 135
16 Preclinical animal models for the investigation of biological approaches to the therapy of neuroblastoma 144
17 Angiogenesis in renal cell carcinomas 156
18 Spontaneous regression and the natural history of renal cell cancer 165
19 Prognostic indicators: localized disease 178
20 Prognostic factors in advanced renal cell carcinoma 186
Pt. I, Sect. 3 Renal cell carcinoma: imaging and management
21 Evaluation of the renal mass and the role of renal biopsy 197
22 Role of the excretory urogram in contemporary uroradiologic practice 224
23 Radiologic imaging: computerized tomography and magnetic resonance imaging 246
24 Ultrasound imaging 258
25 PET imaging in renal cancer 268
26 Therapeutic options for localized disease 273
27 Radical nephrectomy 280
28 Inferior vena caval tumors 285
29 Laparoscopic radical nephrectomy 298
30 Nephron-sparing surgery 309
31 Lymph node dissection 318
32 Surveillance strategies following surgery for renal cell carcinoma 324
33 Adjuvant therapy for renal cell carcinoma 331
34 Complications of surgery for renal cell carcinoma 334
Pt. I, Sect. 4 Renal cell carcinoma: metastatic disease
35 Immunologic therapy for renal cell carcinoma 343
36 Natural history and prognostic factors associated with metastatic renal cell carcinoma 351
37 Radiation therapy: basic sciences 359
38 The use of systemic chemotherapy in the treatment of metastatic renal cell carcinoma 367
39 Interferon for renal cell carcinoma 381
40 The role of interleukin in metastatic renal cell carcinoma 388
41 Adoptive immunotherapy of renal cell cancer 400
42 Immunotherapy for metastatic disease - the French experience 407
43 Cell-based therapy in the treatment of renal cell carcinoma 411
44 Role of nephrectomy in metastatic disease 424
45 Surgical resection of metastases 436
46 Gene therapy for metastatic kidney cancer 447
47 Brain metastases 456
48 Palliative therapy of advanced renal cell carcinoma 471
Pt. 2 Adrenal tumors
49 Imaging of adrenal masses 479
50 Diagnostic tests of adrenal cortical and medullary function 486
51 Selection of patients with incidentally discovered adrenal masses for operation 530
52 Diagnosis and treatment of primary aldosteronism 536
53 Adrenocortical carcinoma 543
54 Pheochromocytoma 550
55 Congenital adrenal hyperplasia: 21-hydroxylase deficiency and 11[beta]-hydroxylase deficiency 558
56 The surgical management of congenital adrenal hyperplasia 566
57 Open adrenalectomy: indications and surgical options 574
58 Partial adrenalectomy: indications and technique 581
59 Lateral transperitoneal laparoscopic adrenalectomy 585
60 Laparoscopic versus open adrenalectomy 591
61 Laparoscopic adrenalectomy by the posterior lumbar approach 598
62 Acute and chronic interstitial cryotherapy of the adrenal 603
Index 609