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1 Lipid Accumulation and Plaque Disruption: Processes Triggering Clinical Instability in Coronary Disease - An Overview 1
2 Expression of 92 kDa Gelatinase in Human Atherosclerotic Lesions Following Recent Plaque Rupture 11
3 Proteinases and Restenosis: Matrix Metalloproteinases and Their Inhibitor and Activator 19
4 Current Concepts of the Plasma Lipoproteins and their Role in Atherosclerosis - An Overview 31
5 Homeostasis of Lipid Oxidation in the Artery Wall 41
6 Molecular Basis for the Lysine Binding Polymorphism of Lipoprotein (a) 45
7 Triglyceride-rich Lipoprotein Metabolism and Diabetes 49
8 Apolipoprotein E: Paradoxes Abound 57
9 The Role of Second Messenger Pathways in the Pathophysiology of Hyperapo-B and Premature Coronary Artery Disease 67
10 The Role of HDL Receptors in Removal of Cellular Cholesterol 75
11 The Defect in HDL[subscript 3] Mediated Efflux of Newly Synthesized Cholesterol is Associated with Impaired Activation of Protein Kinase C in Tangier Fibroblasts 79
12 Cholesterol Efflux from Cells in Culture, Reconstituted Particles, and Whole Serum 89
13 Apo A-1 Containing Particles and Atherosclerosis 97
14 Vascular Endothelium: An Integrator of Pathophysiologic Stimuli in Cardiovascular Disease - An Overview 105
15 Identification of FGF-1-Inducible Genes by Differential Display 109
16 Antioxidants and Endothelial Expression of VCAM-1: A Molecular Paradigm for Atherosclerosis 121
17 Mechanisms of Potentiation of PDGF in Atherosclerosis 129
18 The Regulation of Normal and Pathological Angiogenesis by Vascular Endothelial Factor 133
19 Characterization of Developmentally Associated Changes in Rabbit Vascular Smooth Muscle Cells 145
20 Molecular Basis and Pathologic Consequences of Neutrophil Adherence to Endothelium 153
21 The Distribution of Adhesion Molecules in Normal and Atherosclerotic Arteries and Aortas 159
22 L-Selectin Regulation of Lymphocyte Homing and Leukocyte Rolling and Migration 173
23 L-Selectin, A Lectin-Like Receptor Involved in Normal Lymphocyte Recirculation and Inflammatory Leukocyte Trafficking 185
24 New Perspectives in P-Selectin Biology 191
25 Rat P-Selectin Mediates Neutrophil-Platelet Interactions via Two Sites (23-60, 76-90) Located on Its Lectin Domain 199
26 Regulation of Vascular Fibrinolysis by Type 1 Plasminogen Activator Inhibitor (PAI-1) 205
27 Local Increase in PAI-2 on Stimulation of Monocytes with Modified LDL 211
28 Structure, Function, and Regulation of the Urokinase Receptor 217
29 Role of the LDL Receptor-Related Protein in Proteinase and Lipoprotein Catabolism 223
30 Molecular Biology of Tissue Factor 235
31 Thrombin Receptor: Structure and Function 243
32 Antiplatelet Effects of Direct Acting Thrombin Inhibitors and Platelet GPIIb/IIIa Antagonists: Comparative Analysis 255
33 Biosynthesis of Docosanoids by Human Platelet: Cardiovascular Properties 269
34 The Hemostatic Response to Arterial Injury in vivo: Behavior of Prothrombin at the De-endotheliased Aorta Wall 279
35 Plasma Coagulation Factors in Emergency Room Patients with Acute Chest Pain and Subsequent Hospitalization: Myocardial Infarction, Coronary Artery Disease, and Hypertension 291
36 Genetic Factors Contributing to Atherosclerosis: From Humans to Mice and Back Again 299
37 Genetic Manipulation of Lipoprotein Receptors: Implications for Lipid Metabolism and Atherosclerosis 307
38 Genetic Models of Vascular Disease 313
39 Generation and Characterization of Apolipoprotein C[subscript 1]-Deficient Mice 317
40 Studies of Apolipoprotein B and Lipoprotein(a) in Transgenic Mice 323
41 Isolation of Novel Genes Regulated by Dietary Cholesterol by a PCR-Based Subtraction Library 327
42 Cholesterol and Mortality: What Can Meta-Analysis Tell Us? 333
43 Screening for High Blood Cholesterol: A Risky Enterprise 341
44 Cholesterol Lowering, Low Cholesterol, and Mortality 347
45 Bavarian Cholesterol Screening Project (BCSP) 353
Index 359