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1 CD4+ and CD8+ T Lymphocyte Activation in HIV Infection: Implications for Immune Pathogenesis and Therapy 1
2 Markers of Immune Cell Activation and Disease Progression: Cell Activation in HIV Disease 17
3 The Role of the Cell Cycle in HIV-1 Infection 27
4 Molecular Basis of Cell Cycle Dependent HIV-1 Replication: Implications for Control of Virus Burden 33
5 Regulation of Macrophage Activation and HIV Replication 47
6 Investigations on Autologous T-Cells for Adoptive Immunotherapy of AIDS 57
7 Rational Problems Associated with the Development of Cellular Approaches in Controlling HIV Spread 71
8 The Role of Surface CD4 in HIV-Induced Apoptosis 91
9 Mechanism of Apoptosis in Peripheral Blood Mononuclear Cells of HIV-Infected Patients 101
10 Programmed Death of T Cells in the Course of HIV Infection 115
11 T Cell Apoptosis as a Consequence of Chronic Activation of the Immune System in HIV Infection 121
12 Apoptosis during HIV Infection: A Cytopathic Effect of HIV or an Important Host-Defense Mechanism against Viruses in General? 129
13 From Cell Activation to Cell Depletion: The Programmed Cell Death Hypothesis of AIDS Pathogenesis 139
14 Immunosuppression by a Noncytolytic Virus Via T Cell Mediated Immunopathology: Implication for AIDS 165
15 Clonal Expansion of T Cells and HIV Genotypes in Microdissected Splenic White Pulps Indicates Viral Replication in Situ and Infiltration of HIV-Specific Cytotoxic T Lymphocytes 173
16 Autoimmunity, Apoptosis Defects, and Retroviruses 183
17 AIDS as Immune System Activation: Key Questions that Remain 203
18 Inhibition of T Lymphocyte Activation and Apoptotic Cell Death by Cyclosporin A and Tacrolimus (FK506): Its Relevance to Therapy of HIV Infection 211
19 Cyclophilin and Gag in HIV-1 Replication and Pathogenesis 217
20 Long-Term Follow-up of HIV Positive Asymptomatic Patients Having Received Cyclosporin A 229
21 Prospective Views of HIV Pathology: Clues for Therapeutic Strategies 235
Index 243