Analytical and Quantitative Cardiology: Proceedings of the Tenth Goldberg Workshop Held in Haifa, Israel, December 2-5, 1996, Vol. 430

Author: Samuel Sideman
Published: October 1997
Publisher: Kluwer Academic Publishers
ISBN: 0306457628
Hardcover Book
Number of Pages: 372

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The focus of the conference was the pathway from basic genetics to cardiac function, highlighting the interface between structure and function at all levels of the cardiac system. The 30 papers strive to combine the analytical system approach and engineering principles with the multiple molecular and/or genetic factors and stimuli and the macroscale interactions that determine cardiac function. They cover molecular signalling, the contractile mechanisms and energetics, cardiac mechanics and flow dynamics, vascular structure and remodeling, myocardial structure and function, electrical activation and propagation, and modeling the cardionome. . Sideman, Samuel, DSc (Technion-Israel Institute of Technology); Beyar, Rafael, MD, DSc (Technion-Israel Institute of Technology)The contributors represent the specialties of physiology, bioengineering, pharmacology, biophysics, cardiology, and pathology. Most come from universities and academic medical centers in the U.S., Israel, and the U.K. Institutions prominently represented include Duke, Univ of Vermont, Georgetown, Univ of Oxford, Haddassah Univ, and Chaim Sheba Medical Center.

Table of Contents
Ch. 1 Ca[superscript 2+]-Signaling in Cardiac Myocytes: Evidence from Evolutionary and Transgenic Models 3
Ch. 2 Diastolic Viscoelastic Properties of Rat Cardiac Muscle; Involvement of Ca[superscript 2+] 13
Ch. 3 The Beta Subunit, Kv[beta]1.2, Acts as a Rapid Open Channel Blocker of NH[subscript 2]-Terminal Deleted Kv1.4 [alpha]-Subunits 29
Ch. 4 Signal Transduction in Ischemic Preconditioning 39
Ch. 5 Ca[superscript 2+] Sparks within 200 nm of the Sarcolemma of Rat Ventricular Cells: Evidence from Total Internal Reflection Fluorescence Microscopy 57
Ch. 6 Uncoupling of G-Protein Coupled Receptors In Vivo: Insights from Transgenic Mice 67
Ch. 7 Molecular Control of Myocardial Mechanics and Energetics: The Chemo-Mechanical Conversion 75
Ch. 8 Myocardial Cell Energetics 89
Ch. 9 Human Heart Failure: Determinants of Ventricular Dysfunction 97
Ch. 10 How Cardiac Contraction Affects the Coronary Vasculature 111
Ch. 11 Dynamic Interaction between Myocardial Contraction and Coronary Flow 123
Ch. 12 The Relations between Microvascular Structure and Oxygen Supply 139
Ch. 13 Endothelial Gene Regulation by Laminar Shear Stress 155
Ch. 14 3D Architecture of Myocardial Microcirculation in Intact Rat Heart: A Study with Micro-CT 165
Ch. 15 Vascular Imaging by Ultrasound: 3D Reconstruction of Flow Velocity Fields for Endothelial Shear Stress Calculation 177
Ch. 16 Compensatory Enlargement, Remodeling, and Restenosis 187
Ch. 17 Atherosclerosis Studies by Intracoronary Ultrasound 197
Ch. 18 Tissue Remodeling with Micro-Structurally Based Material Laws 215
Ch. 19 Multiaxial Myocardial Mechanics and Extracellular Matrix Remodeling: Mechanochemical Regulation of Cardiac Fibroblast Function 227
Ch. 20 In Vivo Assessment of Regional Myocardial Work in Normal Canine Hearts Using 3D Tagged MRI 241
Ch. 21 Noninvasive Measurement of Cardiac Strain with MRI 249
Ch. 22 Ventricular Remodeling: From Bedside to Molecule 257
Ch. 23 Cardiac Excitation: An Interactive Process of Ion Channels and Gap Junctions 269
Ch. 24 Modeling of Internal pH, Ion Concentration, and Bioenergetic Changes during Myocardial Ischemia 281
Ch. 25 Gap Junctions: Functional Effects of Molecular Structure and Tissue Distribution 291
Ch. 26 3D Cardiac Imaging of Electromechanical Coupling 303
Ch. 27 Percutaneous Multielectrode Endocardial Mapping and Ablation of Ventricular Tachycardia in the Swine Model 313
Ch. 28 Design and Strategy for the Cardionome Project 325
Ch. 29 Integrative and Interactive Studies of the Cardiac System: Deciphering the Cardionome 341
Ch. 30 Technology vs Physiology: General Discussion 353
Closure 357
The Editors 359
List of Contributors 361
Index 365

Click to compare book prices for Analytical and Quantitative Cardiology: Proceedings of the Tenth Goldberg Workshop Held in Haifa, Israel, December 2-5, 1996, Vol. 430 Analytical and Quantitative Cardiology: Proceedings of the Tenth Goldberg Workshop Held in Haifa, Israel, December 2-5, 1996, Vol. 430

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