The Jak-Stat Pathway in Hematopoiesis and Disease (Molecular Biology Intelligence Unit Series #20)

Author: Alister C. Ward
Published: January 2003
Publisher: Kluwer Academic Publishers
ISBN: 0306474247
Hardcover Book
Number of Pages: 140

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The Janus kinase-signal transducer and activator of transcription (Jak-Stat) pathway plays an important role in the normal development and function of blood cells. This volume presents seven contributions by Ward (cellular and molecular biology, Deakin U., Australia) and other international researchers describing how the Jak-Stat pathway works and how disruptions of this pathway contribute to various hematopoietic disorders, including malignancy. Topics include, for example, the consequences of Jak3 ablation in immunodeficiency syndromes and the negative regulatory function of the SOCS family of proteins.

Table of Contents:

1 Jaks and Normal Hematopoiesis 1
2 Jak3-Dependent Pathways in Hematopoiesis and SCID 10
3 Stat Activation by Src, Fes and Btk Tyrosine Kinases 51
4 Stats and Hematopoiesis 78
5 Stat Signaling in Leukemia: Implications for Pathogenesis and Treatment 92
6 The Role of the Jak-Stat Pathway in Hematopoiesis and Immune Responses in Drosophila 112
7 SOCS Proteins in Hematopoiesis 127
Index 139

Click to compare book prices for The Jak-Stat Pathway in Hematopoiesis and Disease (Molecular Biology Intelligence Unit Series #20) The Jak-Stat Pathway in Hematopoiesis and Disease (Molecular Biology Intelligence Unit Series #20)

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