Immunology of Renal Transplantation

Author: Graeme R. D. Catto
Published: January 1993
Publisher: Arnold, Edward
ISBN: 0340551623
Hardcover Book
Number of Pages: 326

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This book is written by a multidisciplinary group of MDs and PhDs from academic medical centers in the U.S. and abroad. It covers the basic science of transplant immunology and clinical application of immunomodulation in the context of renal transplantation. The stated purpose is to provide a review of basic and clinical immunology of renal transplantation. It provides a very up-to-date examination of the fundamentals of basic transplant immunology and a unique perspective of clinical transplantation that spans from the early days of the discipline to the present and toward the future. The book is written for a broad audience that includes the basic immunologist who wishes to understand more of the clinical realm of renal transplantation and for the clinical transplantologist who desires a stronger knowledge of the rapidly expanding field of structural and molecular immunology of self/nonself discrimination. The book is attractive, with multiple black-and-white, high-quality illustrations that are of sufficient quantity and adequately described. It is a well-referenced book with pertinent current and past references. This is a very valuable book for a broad readership that includes basic immunologists and clinical transplantologists. It contains a rich source of classic references and the most up-to-date information of basic immunology and developments of clinically applied immunomodulation. It is deep, concise, and reads like poetry from its foreword to the final chapter. Thomson, Angus W., PhD, DSc, FRCPath (Univ of Pittsburgh); Catto, Graeme R.D. (Univ of Aberdeen)The contributors are a multidisciplinary group of MDs and PhDs from academic medical centers in the U.S., the U.K., Canada, Australia, France, Holland, and Finland. They are surgeons. immunologists, nephrologists, and transplant specialists. U.S. institutions prominently represented are Harvard, Univ of Pittsburgh, and East Carolina Univ.

Table of ContentsForeword    v
Preface    vi
List of Contributors    ix
SECTION 1 BASIC TRANSPLANTATION IMMUNOLOGY
1 Major and minor histocompatibility antigens    3
2 Presentation and recognition of alloantigens    27
3 T cell responses to alloantigens    51
4 Adhesion molecules, cell trafficking and transplantation    70
5 Cytokine regulation of the immune response to organ transplants    97
6 The role of B cells, antibody and complement    112
SECTION 2 EXPERIMENTAL RENAL TRANSPLANTATION
7 Experimental models of renal allografting    129
8 Induction of specific transplantation tolerance    144
9 Xenografts    157
SECTION 3 CLINICAL RENAL TRANSPLANTATION
10 HLA and ABO matching in clinical renal transplantation    177
11 The blood transfusion effect    188
12 Monitoring ot rejection    202
13 Acute and chronic rejection    221
14 The sensitized patient    235
15 Clinical immunosuppressive drug therapy    255
16 New immunosuppressive drugs: mechanisms of action and early
17 Monoclonal antibody therapy    281
18 Cancer in renal transplant recipients    303
Index    315

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