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Preface
Contributors
Annotation
Introduction
1 The Biological Chemistry of NO 3
2 Role of NO and Nitrogen Intermediates in Regulation of Cell Functions 22
3 Nitric Oxide Synthases and Their Cofactors 52
4 Regulation of the NOS Gene Family 66
5 Role of NO in Cell Locomotion 86
6 Metabolic Pathways and Cycles of L-Arginine Synthesis and Utilization 113
7 Distribution of NOSs in the Kidney 133
8 Vascular Effects of NO 161
9 Role of NO in the Function of the Juxtaglomerular Apparatus 176
10 NOS in Mesangial Cells: Physiological and Pathophysiological Roles 198
11 Tubuloglomerular Feedback and Macula Densa-Derived NO 216
12 NO and the Renin System 233
13 NO and the Medullary Circulation 250
14 NO in Septic Shock 271
15 NO and Glomerulonephritis 307
16 NO in Acute Renal Failure 332
17 NO in Diabetic Nephropathy 349
18 NO and Hypertension 368
19 NO in Normal and Preeclamptic Pregnancy 384
20 Sickle Cell Disease and NO 401
21 A Putative Role of NO and Oxidant Injury in the Pathogenesis of Hemolytic Uremic Syndrome 418
22 Role of NO in Urinary Tract Infections 428
23 Role of the NO System in Urinary Tract Obstruction 443
Index 459