Drugs and Pregnancy

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Author: Larry C. Gilstrap
Published: January 1999
Publisher: Chapman & Hall
ISBN: 0412122014
Hardcover Book
Number of Pages: 523

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Drugs and Pregnancy

This is a review of many over-the-counter, prescription, and illicit medications known to be used in pregnancy. Each chapter reviews a class of medications frequently used for the treatment of a specific disorder. This is a second edition that includes information on current medications used during pregnancy (i.e., antiretrovirals used in HIV-positive pregnant women). Providing ""information to assist the physician in elucidating the effects of drug exposure on pregnancy"" is important when 35 to 85 percent of women report using medications while they are pregnant. The chapter on legal considerations of drugs in pregnancy places the view of both patients and the legal system in historical perspective. The book is written for the generalist caring for pregnant women; although the editors state that it is for obstetricians as well as maternal-fetal medicine subspecialists, the reader is advised on occasion to refer a patient to a specialist by these well-known experts in the field of teratology and medical complications of pregnancy. The number of illustrations is minimal, but they are largely secondary to the subject matter. The illustrations of chemical structure of the medications are particularly helpful in the assessment of similarities within classes of drugs. The book is well referenced, with both historical and current information. The table of contents allows the reader to target a specific disease or class of drugs; the index is extensive and points to information about a given drug that may be used for more than one purpose. The basic information on teratology, specifically differentiating the embryonic from the fetal period is helpful in improving understanding of the useof medications at various times in pregnancy. A guide for obstetricians, maternal-fetal medicine specialists, and others caring for pregnant women. Provides information for the clinical evaluation of pregnant women inadvertently exposed to medications, and advice for the prudent formulation of safe medication regimens to treat pregnant women with specific conditions requiring intervention. Some studies suggest that such exposure happens an average of three times in each pregnancy. Nearly a third of the contributions consider substance abuse. The information is intended to be supplemented with information from the PDR, online teratology information services, and other publications. No date is noted for the first edition. Includes a separate index of drug names. . Gilstrap, Larry C., III, MD (Univ of Texas at Houston); Little, Bertis B., MA, PhD (Univ of Texas Southwestern Medical Center at Dallas)The contributors represent the specialties of pediatrics, radiology, anatomy, neurology, and obstetrics and gynecology. Most come from universities in the U.S., including Univ of Texas Southwestern Medical Center, Univ of Tennessee, and Jefferson Medical Coll.

Table of Contents
Preface
Contributors
Pt. I Introduction: General Principles of Human Teratology, Clinical Evaluation of the Use of Drugs in Pregnancy, Patient Counseling
Ch. 1 Introduction to Drugs in Pregnancy 3
Ch. 2 Human Teratology Principles 7
Ch. 3 Counseling and Evaluation of the Drug-Exposed Pregnant Patient 25
Ch. 4 Legal Considerations of Drugs in Pregnancy 33
Pt. II Medication Use during Pregnancy
Ch. 5 Antimicrobial Agents during Pregnancy 45
Ch. 6 Cardiovascular Drugs during Pregnancy 77
Ch. 7 Antiasthma Agents during Pregnancy 103
Ch. 8 Analgesics during Pregnancy 121
Ch. 9 Anticonvulsant Drugs during Pregnancy 137
Ch. 10 Anticoagulants, Thrombolytics and Hemostatics during Pregnancy 149
Ch. 11 Psychotropics in Pregnancy 161
Ch. 12 Antineoplastic Drugs during Pregnancy 191
Ch. 13 Immunosuppressants during Pregnancy 217
Ch. 14 Endocrine Disorders during Pregnancy: Embryotoxic Versus Fetal Effects 229
Ch. 15 Contraception, Treatment for Infertility and General Hormonal Therapy during Pregnancy 257
Ch. 16 Use of Dermatologics during Pregnancy 273
Ch. 17 Antihistamines, Decongestants and Expectorants during Pregnancy 287
Ch. 18 Gastrointestinal Medications during Pregnancy 295
Ch. 19 Tocolytics 311
Ch. 20 Nutritional and Dietary Supplementation during Pregnancy 321
Ch. 21 Anesthetic Agents and Surgery during Pregnancy 333
Ch. 22 Use of Diagnostic Agents during Pregnancy 347
Ch. 23 Occupational Exposures during Pregnancy 355
Pt. III Substance Abuse during Pregnancy
Ch. 24 Introduction to Substance Abuse during Pregnancy 369
Ch. 25 Drug Overdoses during Pregnancy 377
Ch. 26 Alcohol Use during Pregnancy and Maternal Alcoholism 395
Ch. 27 Amphetamine Abuse during Pregnancy 405
Ch. 28 Cannabinoid Use during Pregnancy 413
Ch. 29 Cocaine Abuse during Pregnancy 419
Ch. 30 Use of Hallucinogens during Pregnancy 445
Ch. 31 Opiate Abuse during Pregnancy 449
Ch. 32 Inhalant (Organic Solvent) Abuse during Pregnancy 457
Ch. 33 Tobacco Use in Pregnancy 463
Ch. 34 Other Substances Abused during Pregnancy 475
Index 485
Drug-Names Index 507

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