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List of contributors
Preface
Pt. 1 Scientific and Diagnostic Principles 1
1 Aetiology and epidemiology 3
2 The genetic basis of children's cancers 27
3 Tumour pathology Section 1: Methodology and specific applications 67
Section 2: Features of specific tumours 93
4 The radiation biology of paediatric tumours 130
5 Clinical applications of radiotherapy 147
6 Cancer chemotherapy and mechanisms of resistance 159
7 Serum markers in tumour diagnosis and treatment 189
8 Design and role of clinical trials 220
Pt. 2 Diagnosis and Management of Individual Cancers 235
9 Acute myeloid leukaemia 237
10 Acute lymphoblastic leukaemia 258
11 Non-Hodgkin's lymphoma 278
12 Hodgkin's disease 296
13 Tumours of the central nervous system 320
14 Retinoblastoma 357
15 Soft tissue sarcomas 380
16 Bone tumours 417
17 Neuroblastoma 443
18 Wilms' tumour 484
19 Malignant germ cell tumours 507
20 Liver tumours 523
21 Langerhans' cell histiocytosis 547
22 Rare tumours 561
Pt. 3 Advances in Therapy, Late Effects and Supportive Care 577
23 Biology and practical aspects of stem cell transplantation 579
24 Megatherapy with stem cell rescue in solid tumours 598
25 Bone marrow transplantation for leukaemia: current controversies 617
26 An overview of the clinical potential of targeted therapy 628
27 Recent advances and future trends in cancer chemotherapy 649
28 Management of acute complications of therapy 677
29 Growth and endocrine function following the treatment of childhood malignant disease 706
30 Other organ sequelae 732
31 The child in the community 749
32 Care of the dying child 757
Appendix Practical guideline tables 769
Index 785