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Molecular toxicologists (Imperial College, London) provide biological information about a skin condition that is estimated to effect between one and four per-cent of the general population worldwide. It may arise following skin contact with a variety of exogenous small molecule sensitizers, xenobiotics that may be encountered commonly in the work place, the natural environment, and the home. Only during recent decades have the specific classes of sensitizing chemicals and the molecular mechanisms in skin that contributes to the condition been investigated. The study was commissioned by the European Cosmetic Toiletry and Perfumery Association.

Table of Contents:

List of figures
List of schemes
List of tables
Acknowledgements
Preface
Ch. 1 Allergic Contact Dermatitis to Small Molecule Xenobiotics 1
Ch. 2 Skin Absorption of Chemical Allergens 19
Ch. 3 Enzymes and Mechanisms of Xenobiotic Metabolism 45
Ch. 4 Enzymes and Pathways of Xenobiotic Metabolism in Skin 87
Ch. 5 Xenobiotics as Skin Sensitisers: Metabolic Activation and Detoxication, and Protein-binding Mechanisms 119
Ch. 6 Protein-hapten Binding and Immunorecognition Events During the Sensitisation and Elicitation Stages of ACD 207
Ch. 7 Conclusion: The Future of In Vitro Models and De Novo Prediction of Xenobiotic Skin Sensitisation, and an MHC-Peptide-Hapten Hypothesis 223
App. I In vivo sensitisation data and physico-chemical properties of xenobiotics (discussed in Chapter 5) 229
App. II Useful web addresses 237
App. III Models and approaches for studying cutaneous metabolism 241
References 245
Index 307