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An international group of specialists wrote the 53 chapters of the 6th edition of this substantial and completely revised reference, which was edited by Hongbo Zhai and Maibach, both affiliated with the U. of California in San Francisco. The editors also co-wrote many of the chapters. Among the topics new to this edition are barrier creams, cosmetic reactions, UV radiation exposure, electron paramagnetic resonance, and hazardous substances in soil and water. Introductory chapters describe aspects of skin permeability, occlusion and barrier function, percutaneous absorption of complex chemical mixtures, anatomical factors affecting barrier function, and the role of lipids in percutaneous absorption. The chapters are grouped into concepts and methods.

Table of Contents:

Contributors
Foreword from the Fifth Edition
Preface to the Sixth Edition
Ch. 1 Skin Permeability 3
Ch. 2 Occlusion and Barrier Function 13
Ch. 3 Percutaneous Absorption of Complex Chemical Mixtures 29
Ch. 4 Anatomical Factors Affecting Barrier Function 43
Ch. 5 Percutaneous Absorption: Role of Lipids 71
Ch. 6 Percutaneous Absorption: Short-Term Exposure, Lag Time, Multiple Exposures, Model Variations, and Absorption from Clothing 83
Ch. 7 Chemical Partitioning into Powdered Human Stratum Corneum: A Useful In Vitro Model for Studying Interaction of Chemical and Human Skin 105
Ch. 8 Sensitive Skin 123
Ch. 9 Transdermal Drug Delivery System - An Overview 137
Ch. 10 Iontophoresis 151
Ch. 11 Irritant Dermatitis (Irritation) 181
Ch. 12 Allergic Contact Dermatitis 229
Ch. 13 Irritant Contact Dermatitis versus Allergic Contact Dermatitis 237
Ch. 14 Molecular Basis of Allergic Contact Dermatitis 265
Ch. 15 Systemic Contact Dermatitis 285
Ch. 16 Permeability of Human Skin to Metals and Paths for Their Diffusion 321
Ch. 17 Photoirritation (Phototoxicity, Phototoxic Dermatitis) 341
Ch. 18 Chemically Induced Scleroderma 353
Ch. 19 Chemical Agents that Cause Depigmentation 375
Ch. 20 Sulfur Mustard: A Chemical Vesicant Model 389
Ch. 21 Carcinogenesis: Current Trends in Skin Cancer Research 409
Ch. 22 Retinoids and Their Mechanisms to Toxicity 419
Ch. 23 Skin Disorders Caused by Cosmetics in China 441
Ch. 24 Drug Induced Ocular Phototoxicity 449
Ch. 25 Water: Is It an Irritant? 471
Ch. 26 Sodium Lauryl Sulfate in Dermatotoxicology 479
Ch. 27 Barrier Creams 507
Ch. 28 Methods for In Vitro Percutaneous Absorption 519
Ch. 29 Tape Stripping Method and Stratum Corneum 531
Ch. 30 Percutaneous Absorption of Hazardous Substances from Soil and Water 549
Ch. 31 Isolated Perfused Porcine Skin Flap 563
Ch. 32 Physiologically Based Pharmacokinetic Modeling 589
Ch. 33 Methods for In Vitro Skin Metabolism Studies 621
Ch. 34 Transdermal Drug Delivery Systems: Dermatologic and Other Adverse Reactions 631
Ch. 35 Predictive Toxicology Methods for Transdermal Delivery Systems 653
Ch. 36 Animal, Human, and In Vitro Test Methods for Predicting Skin Irritation 677
Ch. 37 Analysis of Structural Change in Intercellular Lipids of Human Stratum Corneum Induced by Surfactants: Electron Paramagnetic Resonance (EPR) Study 695
Ch. 38 Test Methods for Allergic Contact Dermatitis in Animals 725
Ch. 39 Test Methods for Allergic Contact Dermatitis in Humans 763
Ch. 40 Immunoadjuvants in Prospective Testing for Contact Allergens 775
Ch. 41 The Local Lymph Node Assay 793
Ch. 42 Contact Urticaria and the Contact Urticaria Syndrome (Immediate Contact Reactions) 817
Ch. 43 An Optimized In Vitro Approach to Assess Skin Irritation and Phototoxicity of Topical Vehicles 849
Ch. 44 Photoirritation (Phototoxicity) Testing in Humans 871
Ch. 45 Measuring and Quantifying Ultraviolet Radiation Exposure 879
Ch. 46 Use of Pig Skin Preparations in Novel Diffusion Cell Arrays to Measure Skin Absorption and to Evaluate Potential Chemical Toxicity 901
Ch. 47 Determination of Subclinical Changes of Barrier Function 937
Ch. 48 Assessing the Validity of Alternative Methods for Toxicity Testing 957
Ch. 49 Animal Models for Immunologic and Nonimmunologic Contact Urticaria 999
Ch. 50 Diagnostic Tests in Dermatology: Patch and Photopatch Testing and Contact Urticaria 1007
Ch. 51 Cosmetic Reactions 1021
Ch. 52 Evaluating Efficacy of Barrier Creams: In Vitro and In Vivo Models 1087
Ch. 53 Light-Induced Dermal Toxicity: Effects on the Cellular and Molecular Levels 1105
Index 1179