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Table of Contents:
Preface
Contributors
1 The uses of biochemical data in clinical medicine 1
2 The acquisition of biochemical data 7
3 The interpretation of biochemical data 15
4 Sodium, water and potassium 25
5 Hydrogen ion homoeostasis, tissue oxygenation and their disorders 61
6 Calcium, phosphate and magnesium 87
7 The kidneys, renal function and renal failure 117
8 Proteinuria 143
9 Renal tubular disorders and renal calculi 163
10 The clinical biochemistry of nutrition 173
11 Malabsorption 199
12 The assessment of hepatic function and investigation of jaundice 217
13 Acute and chronic liver disease 237
14 Diabetes mellitus 257
15 Hypoglycaemia 281
16 Hypothalamic and pituitary disorders 295
17 Adrenal disorders 315
18 Thyroid dysfunction 331
19 Hormonal aspects of non-endocrine disease 355
20 Abnormal sexual development 375
21 Abnormalities of reproductive function 393
22 Pregnancy, oral contraception and hormone replacement therapy 413
23 Paediatric clinical biochemistry 423
24 Biochemical aspects of haemolysis 453
25 Disorders of haem synthesis and the porphyrias 467
26 The haemoglobinopathies 483
27 Paraproteinaemias 493
28 Metabolic bone disease 507
29 Biochemical aspects of articular disease 533
30 Muscle disease 543
31 Investigation of cerebrospinal fluid 557
32 Biochemical aspects of psychiatric disorders 569
33 Biochemical aspects of neurological disease 587
34 Biochemical aspects of mental handicap 599
35 Lipid metabolism, hyper- and hypolipidaemias and atherosclerosis 621
36 Therapeutic drug monitoring 641
37 Poisoning 659
38 Metabolic effects of tumours 679
39 Tumour markers 705
40 Cellular aspects of clinical biochemistry 717
41 Molecular clinical biochemistry 739
42 Free radicals 765
43 Clinical biochemistry in the investigation of acute chest pain and the acute abdomen 779
Index 789
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