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New edition of a text that offers a review of cardiovascular diseases in adults, including discussion of congenital lesions that permit survival to adulthood and the effects of surgical procedures that enable this. Editors Silver (emeritus pathobiology and laboratory medicine, U. of Texas), Avrum I. Gotlieb (laboratory medicine and pathology, U. of Toronto) and Frederick J. Schoen (pathology, Harvard Medical School) have added contributions with new information that reflects advances in clinical practice, in particular in therapeutic intervention. When possible, the molecular biology of disease is emphasized, and newly understood pathologic mechanisms are defined. Some segments help pathologist in daily practice in autopsy or surgical pathology suites. Contains color and b&w illustrations.

Table of Contents:

1 Examination of the Heart and of Cardiovascular Specimens in Surgical Pathology 1
2 Light Microscopy and Ultrastructure of the Blood Vessels and Heart 30
3 Age-Related Cardiovascular Changes 54
4 Atherosclerosis: Pathology and Pathogenesis 68
5 Nonatherosclerotic Diseases of the Aorta and Miscellaneous Diseases of the Main Pulmonary Arteries and Large Veins 107
6 Diseases of Medium- and Small-Caliber Vessels Including Small Arteries, Arterioles, and Capillaries 138
7 Diseases of the Pulmonary Circulation 166
8 Myocardial Cell Death, Including Ischemic Heart Disease and Its Complications 198
9 Myocarditis 256
10 Cardiomyopathies 285
11 Cardiovascular Causes of Sudden Death 326
12 The Pericardium and Its Diseases 375
13 Valvular Heart Disease: General Principles and Stenosis 402
14 Valvular Heart Disease: Conditions Causing Regurgitation 443
15 Interactions Between Heart and Brain 471
16 Cardiovascular Effects of Systemic Diseases and Conditions 493
17 Adverse Effects of Drugs on the Cardiovascular System 541
18 Pathology of the Conduction System 562
19 Tumors and Tumor-Like Conditions of the Heart 583
20 Cardiovascular Trauma 562
21 Pathology of Heart Valve Substitution With Mechanical and Tissue Prostheses 629
22 Pathology of Cardiovascular Interventions, Including Endovascular Therapies, Revascularization, Vascular Replacement, Cardiac Assist/Replacement, Arrhythmia Control, and Repaired Congenital Heart Disease 678
23 Pathology of Cardiac Transplantation 725
24 Genetic Causes of Diseases Affecting the Heart and Great Vessels 763
Index 777