Anesthetic Pharmacology: Physiologic Principles and Clinical Practice

Author: Alex S. Evers
Published: December 2003
Publisher: Elsevier Science
ISBN: 0443065799
Hardcover Book
Number of Pages: 1000

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This beautifully illustrated, full-color text complements offers more in-depth coverage of pharmacology and physiology, especially at the molecular level. This resource is perfect for board preparation, recertification, or for use by clinicians wanting to enhance their understanding of the mechanisms of drug action and find a framework from which they can approach the use of new drugs in practice.Key Features:

Offers more in-depth coverage of physiology than other texts of its kind.
Examines the molecular biology of drugs and organ systems.
Covers the mechanisms of drug action for the latest anesthetic drugs as well as all other drugs that anesthesiologists encounter in practice.
Features comprehensive information on drug interactions.
Complements the text with full-color figures that make every concept crystal clear.
Serves as a perfect resource for board preparation, recertification, or daily clinical use.
Provides a conceptual framework from which clinicians can approach the use of new drugs in practice.
Includes outstanding chapters on Pharmacokinetic and Pharmacodynamic Principles of Drug Action, Signal Transduction Mechanisms, Motor Function, GI/Liver Physiology, Neuroprotective Agents, and Immunosuppressants.

Author Information:
Alex S. Evers, MD, Mallinckrodt Professor and Chairman Department of Anesthesia, Washington University School of Medicine, St.Louis, MO;
Mervyn Maze, MD, Magill Professor of Anesthesia, Intensive Care and Pain Management, Imperial College School of Medicine, London, UK Students, clinicians, and scientists are the intended audience for this comprehensive and practical text. Clearly organized chapters each include a summary and list of references and provide systematic coverage of the mechanisms of action, clinical pharmacology, adverse effects, practical aspects of drug use, and dosage and administration. An initial section is devoted to basic principles, with seven chapters on topics that include pharmacokinetic and pharmacodynamic principles, signal transduction mechanisms, drug biotransformation, and pharmacoeconomics. The remaining 47 chapters are devoted to physiologic substrates of drug action and feature topics that include synaptic transmission, neuromuscular function, autonomic function, cardiac rhythm, myocardial performance, antiarrhythmic agents, vasodilators, and insulin. The text is illustrated with tables, drawings, and diagrams and is authored by specialists worldwide. Evers is with the Washington U. School of Medicine in St. Louis, Missouri; Maze is at the Imperial College London in the UK.

Table of Contents
Pt. I Principles of Drug Action
1 Pharmacokinetic and Pharmacodynamic Principles of Drug Action 3
2 Signal Transduction Mechanisms: Receptor-Effector Coupling 21
3 Signal Transduction Mechanisms: Ion Channels 41
4 Principles of Drug Biotransformation 59
5 Pharmacogenetics and Pharmacogenomics of Drug Action 79
6 Common Pharmacodynamic Drug Interaction in Anesthetic Practice 91
7 Pharmacoeconomics 103
Pt. II Physiologic Substrates of Drug Action
8 The Generation and Propagation of Action Potentials 121
9 Synaptic Transmission 137
10 Neuromuscular Function 157
11 Sensory Processing: Peripheral Nociceptors 173
12 Sensory Processing: Primary Afferent Neuron/Dorsal Root Ganglia 187
13 Sensory Processing: Spinal Cord 199
14 Autonomic Function 209
15 Neural Substrates for Behavior Consciousness 227
16 Neural Substrates for Behavior Pain 245
17 Cardiac Rhythm 257
18 Myocardial Performance 281
19 Vascular Reactivity 297
20 Lung Function 323
21 Renal Physiology 339
22 Liver Physiology 355
Pt. III Pharmacologic Basis of Clinical Practice
23 Inhalational Anesthetics 369
24 Intravenous Anesthetics: Barbiturates, Etomidate, Propofol, Ketamine, and Steroids 395
25 Sedatives, Anxiolytics, and Amnestics 417
26 Analgesics: Nonsteroidal Anti-Inflammatory Drugs 435
27 Analgesics: Receptor Ligands and Opiate Narcotics 457
28 Analgesics: Receptor Ligands -[alpha][subscript 2] Adrenergic Receptor Agonists 473
29 Analgesics: Cannabinoids 491
30 Analgesics: Ion Channel Ligands/Sodium Channel Blockers/Local Anesthetics 507
31 Anticonvulsant Drugs 539
32 Neuroprotective Agents 557
33 Neuromuscular Blocking Agents and Reversal Drugs 573
34 Sympathomimetic, Sympatholytic Drugs, Parasympathomimetic, and Parasympatholytic Drugs 599
35 Antiarrhythmic Agents 621
36 Agents Used to Treat Myocardial Ischemia 641
37 Cardiovascular Pharmacology of Positive Inotropic Drugs 655
38 Myocardial Protection 671
39 Vasodilators 691
40 Bronchodilators, Corticosteroids, and Anti-Inflammatory Agents 703
41 Pulmonary Vasodilators 723
42 Diuretics 733
43 Electrolytes Solutions and Colloids 751
44 Antimotility and Antisecretory Agents 763
45 Antiemetics 777
46 Nutritional Supplements 793
47 Hypothalamic-Pituitary-Adrenal Axis 817
48 Insulin 835
49 Drugs Affecting Lipid Metabolism 853
50 Antimicrobial Therapy 865
51 Chemotherapeutic Agents 887
52 Red Blood Cell Substitutes 909
53 Agents Affecting Coagulation and Platelet Function 927
54 Immunosuppressants 957

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