Clinical Oncology

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Author: Martin D. Abeloff
Published: January 2000
Publisher: Elsevier Science
ISBN: 044307545X
Hardcover Book
Number of Pages: 2963

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Clinical Oncology

The book contains predominantly black-and-white illustrations, with some color illustrations. Completely revised and updated, this 3rd Edition provides you with the latest developments in basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention. The addition of basic science editor Michael B. Kastan, MD, PhD ensures complete coverage of essential scientific topics. And, a new templated, full-color design -- with highlighted boxes and algorithms -- offers easy access to pertinent information. New edition of a text that examines all aspects of the treatment of cancer by integrating expert perspectives from the disciplines of oncology (medical, surgical, and radiation) and hematology. The 96 contributions reflect the latest developments in basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention. Topics include the science of clinical oncology (genetic, immunologic, and environmental bases of cancer; principles of prevention, diagnosis, and therapy; and understanding risk); general, hematologic, metabolic, and surgical problems common to cancer and its therapy; local effects of cancer and its metastasis; specific malignancies; and rehabilitation of the cancer patient. The volume begins with a section of color plates, and in addition contains about 1,000 figures, algorithms, flow diagrams, and tables. Each chapter includes an outline summary of key facts. Edited by Abeloff (Johns Hopkins U. and Hospital), James O. Armitage (U. of Nebraska Medical Center), Allen S. Lichter (U. of Michigan Medical Center), and John E. Niederhuber (U. of Wisconsin Medical School). Abeloff, Martin D., MD (Johns Hopkins Univ); Armitage, James O., MD (Univ of Nebraska); Lichter, Allen S., MD (Univ of Michigan); Niederhuber, John E., MD (Stanford Univ)The contributors represent the specialties of oncology, hematology, general medicine, internal medicine, pathology, dermatology, radiation oncology, urology, pediatrics, obstetrics and gynecology, and orthopedics. Most are from U.S. academic medical centers, but a few are from Canada, the U.K., France, Belgium, and Switzerland. Institutions prominently represented include Univ of Nebraska, Univ of Texas MD Anderson Cancer Center, Loyola, Stanford, Johns Hopkins Oncology Center, Univ of Michigan, St Joseph's Hospital and Medical Center (Phoenix), Vanderbilt, Univ of Rochester, Brown, Memorial Sloan-Kettering Cancer Center, Mayo Clinic, USC, Medical Coll of Virginia, Wayne State, Emory, Scripps Clinic and Research Center, UCLA, and Roswell Park Cancer Institute.

Table of Contents
Pt. I Science of clinical oncology 1
1 Molecular tools in cancer research 3
2 Intracellular signaling 19
3 The cellular microenvironment 47
4 Biology of cancer metastasis 59
5 Control of the cell cycle 81
6 Cell life and cell death 101
7 Immunology and cancer 113
8 Stem cells, cell differentiation, and cancer 139
9 Vascular and interstitial biology of tumors 153
10 Environmental factors 173
11 DNA damage response pathways and cancer 191
12 Viruses and human cancer 207
13 Genetic factors : hereditary cancer predisposition syndromes 227
14 Genetic factors : finding cancer susceptibility genes 253
15 Progressing from gene mutations to cancer 269
16 Immunodeficiency and cancer 287
17 Pathology and laboratory medicine 299
18 Imaging 341
19 Biostatistics for clinical trials 365
20 Structures supporting cancer clinical trials 383
21 Economic analysis of cancer treatment 395
22 Epidemiology and population sciences 407
23 Cancer prevention, screening, and early detection 425
24 Smoking cessation : current treatments and future directions 473
25 Chemotherapy 483
26 The basics of radiation therapy 537
27 Surgical interventions in cancer 579
28 Bone marrow transplantation 591
29 Gene therapy in oncology 603
30 The present and future of molecularly targeted therapy 623
31 Photodynamic therapy 639
32 Therapeutic antibodies and immunologic conjugates 661
33 Cancer vaccines 677
34 Complementary and alternative medicine 695
Pt. II Problems common to cancer and its therapy 713
35 Cancer pain 715
36 Rehabilitation of the patient with cancer 731
37 Cachexia 749
38 Nausea and vomiting 759
39 Oral complications 775
40 Alopecia and cutaneous complications 793
41 Lymphedema 817
42 Fatigue 835
43 Caring for patients at the end of life 847
44 Disorders of blood cell production in clinical oncology 861
45 Diagnosis, treatment, and prevention of cancer-related venous thrombosis 891
46 Fever in the neutropenic cancer patient 925
47 Infection in the severely immunocompromised patient 941
48 Hypercalcemia 957
49 Hyponatremia 973
50 Tumor lysis syndrome 987
51 Paraneoplastic neurologic syndromes 993
52 Establishing and maintaining vascular access 1007
53 Acute abdomen, bowel obstruction, and fistula 1025
54 Superior vena cava syndrome 1047
55 Spinal cord compression 1063
56 Brain metastases and carcinomatous meningitis 1073
57 Bone metastases 1091
58 Lung metastases 1129
59 Liver metastases 1141
60 Effusions 1179
61 Neurologic complications 1213
62 Pulmonary complications of anticancer treatment 1237
63 Cardiac effects of cancer therapy 1251
64 Reproductive complications 1269
65 Endocrine complications 1287
66 Second malignant neoplasms 1297
67 Cancer in the elderly : biology, prevention, and treatment 1317
68 Special issues in pregnancy 1331
Pt. III Specific malignancies 1345
69 Cancer of the central nervous system 1347
70 Eye, orbit, and adnexal structures 1433
71 Cancer of the head and neck 1497
72 Melanoma 1561
73 Nonmelanoma skin cancers : basal cell and squamous cell carcinomas 1589
74 Cancer of the endocrine system 1611
75 Cancer of the lung : NSCLC and SCLC
76 Tumors of the pleura and mediastinum 1745
77 Cancer of the esophagus 1787
78 Cancer of the stomach 1819
79 Cancer of the small bowel 1863
80 Colon cancer 1877
81 Cancer of the rectum 1943
82 Cancer of the anal canal 1967
83 Liver and bile duct cancer 1981
84 Carcinoma of the pancreas 2015
85 Kidney and ureter 2035
86 Carcinoma of the bladder 2059
87 Prostate cancer 2085
88 Cancer of the penis and urethra 2149
89 Testicular cancer 2175
90 Cancers of the cervix, vagina, and vulva 2217
91 Cancer of the uterus 2273
92 Ovarics and fallopian tubes 2311
93 Gestational trophoblastic disease 2347
94 Cancer of the breast 2369
95 Sarcomas of bone 2471
96 Sarcomas of soft tissue 2573
97 Unknown primary cancer 2627
98 HIV-associated malignancies 2647
99 Pediatric solid tumors 2661
100 The world health organization classification of hematologic malignancies 2723
101 Childhood leukemia 2731
102 Childhood lymphoma 2765
103 Acute lymphoid leukemia in adults 2793
104 Acute myeloid leukemia in adults 2825
105 The myelodysplastic syndromes 2849
106 Chronic myeoloproliferative diseases 2883
107 Chronic myeloid leukemia 2899
108 Chronic lymphoid leukemias 2921
109 Hairy cell leukemia 2941
110 Multiple myeloma and related disorders 2955
111 Hodgkin's lymphoma 2985
112 Non-Hodgkin's lymphoma 3015
113 Cutaneous T-cell lymphoma and cutaneous B-cell lymphoma 3077
114 Adult T-cell leukemia-lymphoma 3109

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