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Sect. I Issues Relevant to the Pre-Transplant Period 1
Ch. 1 Aplastic Anemia 2
Ch. 2 Acute Myelogenous Leukemia 14
Ch. 3 Acute Lymphoblastic Leukemia 31
Ch. 4 Chronic Myelogenous Leukemia 39
Ch. 5 Myelodysplasia 49
Ch. 6 Hodgkin Disease 63
Ch. 7 Lymphoma 76
Ch. 8 Multiple Myeloma 83
Ch. 9 Chronic Lymphocytic Leukemia 95
Ch. 10 Breast Cancer 100
Ch. 11 Ovarian Cancer 117
Ch. 12 Childhood Solid Tumors 126
Ch. 13 Germ Cell Tumors 145
Ch. 14 Hematopoietic Stem Cell Transplantation for Treatment of Congenital Immunodeficiencies 154
Ch. 15 Metabolic Diseases 169
Ch. 16 Hemoglobinopathies 185
Ch. 17 Gaucher Disease 193
Ch. 18 Hematopoietic Stem Cell Transplantation for Severe Autoimmune Disease: Know Thyself 203
Ch. 19 In Utero Transplantation 217
Ch. 20 Evaluation of Patients Before Hematopoietic Stem Cell Transplantation 225
Ch. 21 Histocompatibility 233
Ch. 22 Choice of Donor 253
Ch. 23 Long-Term Venous Access During Hematopoietic Stem Cell Transplantation 259
Ch. 24 Bone Marrow Harvesting 265
Ch. 25 Peripheral Blood Progenitor Cell Mobilization and Collection 269
Ch. 26 Cord Blood Stem Cells 287
Ch. 27 Stem Cell Quantification: The ISHAGE Guidelines for CD34+ Determination - Applications in Autologous and Allogeneic Hematopoietic Stem Cell Transplantation 298
Ch. 28 Graft Processing, Storage and Infusion 312
Ch. 29 Purging of Contaminating Tumor Cells 322
Ch. 30 T-Cell Depletion and Allograft Engineering 335
Ch. 31 Immunomodulation After Transplantation 345
Ch. 32 Ex Vivo Stem Cell Expansion 355
Ch. 33 Hematopoietic Stem Cells as Targets for Gene Therapy 364
Sect. II Issues Relevant to the Immediate Transplant Period 381
Ch. 34 High-Dose Chemotherapy Conditioning Regimens for Autologous or Allogeneic Hematopoietic Stem Cell Transplantation 382
Ch. 35 Choice of Conditioning Regimens 403
Ch. 36 Viral Infections 414
Ch. 37 Bacteria 424
Ch. 38 Fungi and Other Organisms 435
Ch. 39 Prevention of Acute Graft-Versus-Host Disease 452
Ch. 40 Use of Hematopoietic Growth Factors 471
Ch. 41 Coagulopathy During Transplantation 488
Ch. 42 Nutritional Issues and Management in Hematopoietic Stem Cell Transplantation 503
Sect. III Complications 509
Ch. 43 Infection 510
Ch. 44 Failure of Engraftment 521
Ch. 45 Therapy of Acute Graft-Versus-Host Disease 531
Ch. 46 Liver Disease in Hematopoietic Stem Cell Transplant Recipients 541
Ch. 47 Mucositis and Other Gastrointestinal Complications 557
Ch. 48 Respiratory Complications 563
Ch. 49 Neurologic Complications 578
Ch. 50 Transfusion Support in Hematopoietic Stem Cell Transplantation 589
Ch. 51 Surgical Emergencies 599
Ch. 52 Late Graft Failure 603
Ch. 53 Infection and Immunization 608
Ch. 54 Chronic Graft-Versus-Host Disease 614
Ch. 55 Endocrine and Metabolic Complications 625
Ch. 56 Relapse After Hematopoietic Stem Cell Transplantation: Mechanisms and Treatment 637
Ch. 57 Myelodysplasia and Second Malignancies 647
Sect. IV Post-Transplant Therapy 659
Ch. 58 Biologic Therapy After Hematopoietic Stem Cell Transplantation 660
Ch. 59 Post-Transplant Cytotoxic Therapy 667
Sect. V Associated Issues 671
Ch. 60 Psychosocial Considerations: A Family Approach to Patient Care 672
Ch. 61 Specialized Nursing 683
Ch. 62 Coordination and Data Collection 688
Ch. 63 Biostatistics 697
Ch. 64 Economics 712
Sect. VI Regulatory Issues 721
Ch. 65 Regulation of Hematopoietic Stem Cell Therapy 722
Index 733