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Carcinogenesis. Tobacco carcinogenesis and head and neck cancer (S.P. Schantz, N.K. Lee). Attempts to transform human tracheal epithelium in vitro with chemical carcinogens (P. Koldovsky, H. Bier). The influence of ethanol on a squamous cell carcinoma cell line of the head and neck (A.F.P. Temmel et al.). Carcinogenesis of head and neck cancer by ionizing radiation (B.N. Kimming, R. Wilhelm). Continuous cell lines derived from head and neck tumors for mechanistic studies in vitro and in nude mouse animal model (J.W. Knebel et al.). Genetic alterations. Correlation between 11q13 amplifications and node invasion in head and neck carcinoma (O. Parise et al.). A specific clinical subset of pleomorphic adenomas (PA) due to HMGI-C mutations? (C. Rohen et al.). Cytokines. Epidermal growth factor receptor in head and neck squamous cell carcinomas (H. Bier, T. Hoffmann). Immunotherapy of operable squamous cell carcinoma of the oral cavity and oropharynx (A. De Stefani et al.). p53. Clinical utility of p53 analysis in human neoplasia: application to head and neck cancer (T. Soussi et al.). Serum p53-antibodies in head and neck cancer (J.D. Maass et al.). Virus cofactors. Association between HPV presence and age in oral squamous cell carcinomas (I. Cruz et al.). Human papillomavirus (HPV) in laryngeal carcinomas (O. Arndt, K. Zeise, J. Brock). Histological evaluations. The importance of endogenous fluorescence to the visual demarcation of squamous cell carcinomas of theupper aerodigestive tract (A. Fryen et al.). Prognostic factors. Cathepsin D: an independent prognostic factor for lymph node metastasis of laryngeal cancer (M. Maurizi et al.). Prognostic factors in squamous cell neoplasias of the upper aero-digestive tract (J. Olofsson, W. Golusinski). Tumor markers. The tumor marker CYFRA 21-1 in the diagnosis of head and neck tumors (C. Motsch, H. Künne). Tumor markers in cancers of the thyroid gland (W. Brenner, K.H. Bohuslavizki, E. Henze). Biology and chemoprevention. Prevention of squamous cell carcinomas of the upper aerodigestive tract (P. Ambrosch). Malignant melanoma. Cellular immune response against malignant melanoma (S.N. Wagner). Cancer vaccines in melanoma: studies in man and in experimental animals (A. Schneeberger et al.). Index of authors. Keyword index.