Mechanisms of Drug Resistance in Epilepsy - No. 243: Lessons from Oncology

Author: Novartis Foundation Symposium
Published: April 2002
Publisher: Wiley, John & Sons, Incorporated
ISBN: 047084146X
Hardcover Book
Number of Pages: 254

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Drug resistance in epilepsy is an important clinical problem. About 200f patients diagnosed as having epilepsy fail to respond to prescribed antiepileptic drugs and continue to have seizures. But despite the size of the problem, remarkably little attention has been paid to the biological basis of refractory epilepsy. Recent work has shown that brain tissue from some patients with epilepsy shows increased expression of a protein that mediates drug resistance in cancer, P glycoprotein. But while resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken with some success, resistance in epilepsy has only just begun to be addressed. This novel book brings together, for the first time, epilepsy researchers and oncologists, with a view to stimulating further work on drug resistance in epilepsy. Successfully bridging the two fields, the stimulating discussions contained in this book should be of great interest to those working on cancer resistance and refractory epilepsy alike.

Table of Contents:

Chair's introduction 1
The problem of the drug-resistant epilepsies 4
Drug resistance molecules: lessons from oncology 19
Drug resistance in epilepsy: the role of the blood-brain barrier 38
P glycoprotein and the mechanism of multidrug resistance 54
Drug resistance caused by multidrug resistance-associated proteins 69
Reversal of multidrug resistance: lessons from clinical oncology 83
Clinical development of P glycoprotein modulators in oncology 103
Gene expression profiling of epothilone A-resistant cells 119
Imaging of P glycoprotein function in vivo with PET 137
Animal models of drug-resistant epilepsy 149
Drug resistance in epilepsy: human epilepsy 167
Cellular mechanisms of pharmacoresistance in slices from epilepsy surgery 186
Functional polymorphisms of the human multidrug resistance (MDR1) gene: correlation with P glycoprotein expression and activity in vivo 207
OC144-093, a novel P glycoprotein inhibitor for the enhancement of anti-epileptic therapy 213
Final general discussion 231
Closing remarks 236
Index of contributors 237
Subject index 239

Click to compare book prices for Mechanisms of Drug Resistance in Epilepsy - No. 243: Lessons from Oncology Mechanisms of Drug Resistance in Epilepsy - No. 243: Lessons from Oncology

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