Etiology of Breast and Gynecological Cancers, Vol. 396

Author: C. Marcelo Aldaz
Published: March 1997
Publisher: Wiley, John & Sons, Incorporated
ISBN: 0471169013
Hardcover Book
Number of Pages: 296

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Despite recent advances in research and prevention, the incidence of common female cancers is still increasing. This book reviews the most recent advances in the fields of breast and gynecological carcinogenesis. It discusses the validity of animal models for study of these human diseases and addresses the relative contributions of genetic predisposition and environmental exposure to potential carcinogens including environmental hormone disrupters. Reviews the most recent advances in the field of breast and gynecological cancers. Discusses environmental influences that play a role in hormone-mediated neoplasias.

Table of Contents:

Contributors
Preface
Acknowledgments
Toward a Unified Concept of Mammary Carcinogenesis 1
Epidemiologic Analysis of Breast and Gynecologic Cancers 17
Recent Advances in the Molecular Genetics of Hereditary Breast and Ovarian Cancer 31
Defining Etiologic Heterogeneity in Breast Cancer Using Genetic Biomarkers 53
The Genetics of Sporadic Breast Cancer 63
Molecular Epidemiology of Breast Cancer 83
Molecular Perspectives on Cancer, the Cell Cycle and the Inherited Disorder Ataxia-Telangiectasia 101
Radiation and Breast Cancer Risk 115
Genotoxicity of Environmental Agents in Human Mammary Epithelial Cells: A Trigger for Human Breast Cancer 125
Organochlorine Exposure and Risk for Breast Cancer 133
Diet and Breast Cancer: Opportunities for Prevention and Intervention 147
Perspectives and Progress in Development of Breast Cancer Chemopreventive Drugs 159
The Molecular Genetics of Endometrial Carcinoma 185
Rodent Model of Reproductive Tract Leiomyomata: Characterization and Use in Preclinical Therapeutic Studies 205
Mechanisms of DES Carcinogenicity: Effects of the TGF[alpha] Transgene 217
Estrogens and The Genetic Control of Tumor Growth 233
Targeted Antiestrogens 245
The Metabolism and Genotoxicity of Tamoxifen 257
Tamoxifen Breast Cancer Prevention Trial - An Update 271
Index 283

Click to compare book prices for Etiology of Breast and Gynecological Cancers, Vol. 396 Etiology of Breast and Gynecological Cancers, Vol. 396

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