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Table of Contents:

Foreword
Preface
Contributors
I Basic Science: Overview
1 Overview of Basic Mechanisms Underlying Neuropathological Consequences of Head Trauma 3
2 In Vitro Models of Traumatic Brain Injury 37
3 Contemporary in Vivo Models of Brain Trauma and a Comparison of Injury Responses 65
II Preclinical Studies
4 The Role of Glutamate Receptors in the Pathophysiology of Traumatic Brain Injury 87
5 Cholinergic Receptors in Head Trauma 115
6 Adenosine Receptor Activation in Traumatic Brain Injury 141
7 Growth Factors 165
8 The Inflammatory Response as a Therapeutic Target in Traumatic Brain Injury 189
9 Contribution of Ionic Alterations to Metabolic Dysfunction Following Traumatic Brain Injury 203
10 Contribution of Calpains and Caspases to Cell Death Following Traumatic Brain Injury 219
11 Apoptosis and DNA Damage 239
12 Mitochondrial Dysfunction Following Traumatic Brain Injury 257
13 Traumatic Axonal Injury 281
14 Vascular Aspects of Severe Head Injury 303
III Clinical Directions
15 Epidemiology and Economics of Head Trauma 327
16 Clinical Presentation and Neuropsychological Sequelae of Traumatic Brain Injury 349
17 The American Brain Injury Consortium 371
18 Guidelines for Medical and Surgical Management in Head Trauma Patients in the United States and Europe 385
19 Clinical Trials in Head Injury: United States 417
20 Clinical Trials in Head Injury: Europe 433
21 Clinical Trials in Head Injury: Asia 461
Appendix 481
Index 485