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Providing an overview of current research, this book gives particular attention to the techniques of flow cytometry, especially its implications for the observation of HIV infection and the immune system's response to it. Grouped by topic, 21 chapters discuss molecules, cells, pathophysiological processes, technologies, and organisms. Contributors include immunologists, virologists, microbiologists, and other researchers from the United States and Europe.

Table of Contents:

Preface
Contributors
Pt. I Molecules 1
1 HIV and Molecular Biology of the Virus-Host Interplay 3
2 Telomere Length, CD28[superscript -] T Cells, and HIV Disease Pathogenesis 13
3 Immune Dysregulation and T-Cell Activation Antigens in HIV Infection 33
4 Quantification of HIV/SIV Coreceptor Expression 53
Pt. II Cells 67
5 B Cells in the Line of Sight of HIV-1 69
6 Cytotoxic T-Cell (CTL) Function in HIV Infection 103
7 Analysis of the [alpha]/[beta] T-Cell Receptor Repertoire in HIV Infection 127
8 Gamma-Delta ([gamma][delta]) T Cells and HIV-1 Infection 147
9 Natural Killer Cells in HIV Infection and Role in the Pathogenesis of AIDS 183
10 Alveolar Macrophages 207
11 Dendritic Cells Ferry HIV-1 from Periphery into Lymphoid Tissues 229
Pt. III Processes 249
12 Homeostasis and Restoration of the Immune System in HAART-Treated HIV-Infected Patients: Implications of Apoptosis 251
13 Mitochondria Functionality During HIV Infection 269
14 Multiple Roles of Cytokines in HIV Infection, Replication, and Therapy 293
Pt. IV Technologies 313
15 The Use of Peptide/MHC Tetramers to Visualize, Track, and Characterize Class I-Restricted Anti-HIV T-Cell Response 315
16 Tagging of HIV with Green Fluorescent Protein 333
17 Flow Cytometric Analysis of Cells from Persons with HIV-1 Disease by Enzymatic Amplification Staining 351
18 Antigen-Specific Cytokine Responses in HIV Disease 371
Pt. V Organisms 383
19 Chimeric Models of SCID Mice Transplanted with Human Cells: The Hu-PBL-SCID Mouse and Its Use in AIDS Research 385
20 Immune Reconstitution of the CD4 T-Cell Compartment in HIV Infection 399
21 New Perspectives in Antiretroviral Therapy of HIV Infection 423
Index 439