Enzyme Systems that Metabolise Drugs and Other Xenobiotics

Author: Costas Ioannides
Published: January 2002
Publisher: Wiley, John & Sons, Incorporated
ISBN: 0471894664
Hardcover Book
Number of Pages: 588

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This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:enzyme function in the metabolism and bioactivation of xenobioticssubstrate specificitytissue distributionspecies distribution (to include laboratory animals and humans)hormonal regulationsex differencesmodulation by prior exposure to other chemicalsage-dependent expressionpharmacogenetics and modulation by disease.Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.

Table of Contents:

Chapter 1: Overview of drug metabolism
Chapter 2: Cytochromes P450
Chapter 3: Flavin monooxygenases
Chapter 4: Monoamine oxidases
Chapter 5: Molybdenum hydroxylases
Chapter 5: Prastaglandin systhetases
Chapter 5: Alcohol and acetaldehyde dehydrogenases
Chapter 6: Oxidoreductases
Chapter 7: Lipoxygenases
Chapter 8: Glucuronyl transferases
Chapter 9: Glutathione S-transferases
Chapter 10: Sulphotransferases
Chapter 11: N-Acetyltransferases
Chapter 12: Epoxide hydrolases
Chapter 13: Methyl transferases
Chapter 14: Amino acid conjugases
Chapter 15: Deconjugating enzymes
Chapter 16: Enzymes involved in nitro-reductions
Chapter 17: Non-enzymic metabolism of drugs

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