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Immunodiagnostic Approaches in Schistosomiasis

Author: N. R. Bergquist
Published: May 1992
ISBN: 0471934011
Hardcover Book
Number of Pages: 152
 
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Immunodiagnostic Approaches in Schistosomiasis


All the latest available information has been collated to cover such diverse topics in schistosomiasis serology as antigen and antibody detection; the discovery of antigens in body excretions employing such modern techniques as hybridoma and recombinant DNA technology. Features a proposed strategy for improving and moving serological methods from the bench into national control programs. Also describes standardized testing systems which would permit valid comparisons between various areas. Provides support for decisions regarding national health policies.


Table of Contents:


Contributors
Immunodiagnosis of Schistosomiasis 1
Community-Based Immunodiagnosis of Schistosomiasis 9
Serological Techniques for Diagnosing Schistosomiasis in the Individual 17
Collaborative Study on Antigens and Methods for Immunodiagnosis of Schistosomiasis in China. Background and Study Design
Field Trials for Immunodiagnosis with Reference to Schistosoma mansoni 39
Seroepidemiology of Schistosomiasis Mansoni in Kenya Using Crude and Purified Schistosoma mansoni Egg Antigens: Results of a Field Trial 49
Evaluation of Recombinant Schistosoma mansoni Antigens Sm31 and Sm32 for Immunodiagnosis 59
Alternative Preparation of Schistosoma Egg Antigens for Circumoval and Intraoval Precipitin Tests for Use in Endemic Areas 71
Immunodiagnosis Based on Enzyme Markers 83
Antigen Detection in Urine Samples for the Diagnosis of Schistosomiasis 103
Detection of the Circulating Anodic Antigen for Immunodiagnosis of Schistosoma Infections 111
The Use of Recombinant DNA Methods to Produce Schistosoma Antigens in order to Assess their Immunodiagnostic Potential: Schistosoma mansoni Tropomyosin an Example 125
Conclusions and General Recommendations 133


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Immunodiagnostic Approaches in Schistosomiasis





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