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Table of Contents:
Introduction 1
Motor neuron disease and model systems: aetiologies, mechanisms and therapies
Potential utility of rhIGF-1 in neuromuscular and/or degenerative disease 18
Therapeutic potential of the neurotrophins and neurotrophin-CNTF combinations in peripheral neuropathies and motor neuron diseases 39
Development of neurotrophic factor therapy for Alzheimer's disease
Growth factor function in the development and maintenance of midbrain dopaminergic neurons: concepts, facts and prospects for TGF-[beta] 70
Somatic gene therapy for nervous system disease 85
Neurotrophic factors in the treatment of peripheral neuropathy 108
Growth factors in the treatment of degenerative retinal disorders 120
Effects of neurotrophins on the survival and regrowth of injured retinal neurons 144
Neurotrophic factors as pharmacological agents for the treatment of injured auditory neurons 149
Growth factors as potential drugs for the sensory epithelia of the ear 167
Factors affecting neuronal birth and death in the mammalian olfactory epithelium 188
The problems of delivering neuroactive molecules to the CNS 211
Closing remarks 240
Index of contributors 241
Subject index 243
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