Abnormalities of IgG Glycosylation and Immunological Disorders

Author: David A. Isenberg
Published: January 1996
Publisher: Wiley, John & Sons, Incorporated
ISBN: 0471962600
Hardcover Book
Number of Pages: 280

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In the past decade the field of glycosylation has become the focus of considerable research with particular emphasis being placed on the glycosylation of human immunoglobulins, notably IgG. This volume collates and reviews all aspects of the immunoglobulin glycosylation abnormalities reported over the past decade.

Table of Contents:

Contributors
Foreword
1 The Defining Characteristics of Immunoglobulin Glycosylation 1
2 Analytical Methods 1: Biochemical 45
3 Analytical Methods 2: Lectins 65
4 Analytical Methods 3: Monoclonal Antibodies 89
5 Glycosylation of IgG in Rheumatic Diseases 101
6 Fc Glycosylation and Rheumatoid Factors 119
7 The Role of Agalactosyl IgG in Rodent Models of Autoimmune Disease and in the Pathogenesis of Rheumatoid Arthritis 131
8 The Glycosyltransferases 149
9 The Glycosyltransferase Genes 171
10 The Disease Distribution and Pathogenetic Significance of a Raised Percentage of Agalactosyl IgG 201
11 Immunoglobulins Carry Infectious Non-self Mimetic Carbohydrate Residues. Implications for the Function of Antibodies in Health and Disease 221
12 Summary and Overview 253
Index 257

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