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Table of Contents:

List of Contributors
Preface
Introduction to Endocrine and Hormonal Toxicology
Abbreviations
Sect. I An Integrated Approach to Endocrine and Hormonal Toxicology 1
1 Endocrine and Hormonal Toxicology: An Integrated Mechanistic and Target Systems Approach 3
Sect. II Endocrine Organs as Toxicological Targets 13
2 Pituitary Toxicology: Direct Toxicity, Secondary Changes and Effects on Distal Target Tissues 15
3 Thyroid and Parathyroid Toxicology 33
4 Adrenal Toxicology 67
5 Testicular Toxicology 91
6 Ovarian Toxicology 111
7 Pancreatic Toxicology 125
8 Comparative Endocrine Carcinogenesis 155
Sect. III Endocrine and Hormonal Toxicology: A Target System Approach 169
9 Neuroendocrine and Pituitary Toxicity: Targets for Drug Action and Potential Consequences on Immune Function 171
10 Hormonal Mechanisms in Neurotoxicity 209
11 Hormonal Mechanisms in Cardiovascular Toxicity 227
12 Hormonal Mechanisms in Gastrointestinal Toxicity 275
13 Hormonal Mechanisms in Kidney Toxicity 291
14 Hormonal Mechanisms in Liver Cancer 309
15 Hormonal Mechanisms in Skin Toxicity 327
16 Hormonal Mechanisms in Male Reproductive Tract Toxicity 355
17 Hormonal Mechanisms in Female Reproductive Tract Toxicity 407
Sect. IV Endocrine Toxicology: Human and Environmental Health Perspectives 419
18 Endocrine Disrupting Chemicals: The Evidence for Human Health Effects 421
19 Chemically-Induced Oestrogenic and Anti-Oestrogenic Activity: Structure-Dependent Effects and Molecular Mechanisms of Action 461
20 Hormonal Mechanisms in Breast Cancer 487
21 Current and Regulatory Trends in Endocrine and Hormonal Toxicology 507
22 The Endocrine-disrupting Properties of Dioxin (TCDD): The Potential Role of the Adrenal Cortex and Glucocorticoid Receptor in Contributing to the Dioxin Toxicity Syndrome 535
Index 555