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Cell Therapy: Stem Cell Transplantation, Gene Therapy, and Cellular Immunotherapy

Author: George Morstyn
Published: April 1996
Publisher: Cambridge University Press
ISBN: 0521473152
Hardcover Book
Number of Pages: 617
 
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Cell Therapy: Stem Cell Transplantation, Gene Therapy, and Cellular Immunotherapy


This volume in the series Cancer: Clinical Science in Practice, examines the current state and future prospects of hematopoietic cell therapy, which seems likely to have an even more profound impact on health care than did the production of proteins by recombinant DNA technology. The coverage is broad, including the scientific principles of cell therapy and gene therapy, the technology of cell collection and preparation, current and likely future clinical applications of cell therapy, and the principles and practice of cellular immunotherapy.


Table of Contents:


Contributors
Glossary of Terms
1 Overview of Hemopoiesis and Hemopoietic Reconstruction
2 Effector Cells of Experimental and Clinical Cellular Adoptive Immunobiology
3 Current and Potential Uses of Defined Cell Populations
4 Human Progenitor Cell Assays
5 Flow Cytometric Techniques
6 Principles of Gene Therapy
7 Sources of Hemopoietic Progenitor Cells for Transplantation
8 Chemotherapy-Based Approaches to Mobilization of Progenitor Cells
9 Cytokine-Only Approaches to Mobilization of Progenitor Cells
10 Characterization and Isolation of Mobilized Peripheral Blood Stem Cells Using a High-Speed Cell Sorter
11 Hemopoietic Stem Cell Selection Using Monoclonal Antibodies
12 Magnetic Approaches to Cell Separation
13 Growth Factors and Ex Vivo Expansion of Hemopoietic Progenitor Cells
14 Bioreactors for Expansion
15 Purging of Malignant Cells
16 Dose-Intensive Chemotherapy without Hemopoietic Cell Support
17 Clinical Potential of Hemopoietic Growth-Factor Support for High-Dose Chemotherapy
18 Treatment of Solid Tumors with High-Dose Chemotherapy Requiring Cellular Support
19 High-Dose Chemotherapy with Cellular Support for Hematological Malignancies
20 Allogeneic Marrow Transplantation as Treatment for Myeloid Malignancies: Why it Works and How it Might Be Improved
21 Clinical Gene Therapy
22 Gene Therapy of Enzyme and Immune Deficiencies in the Hemopoietic System
23 Cellular Therapy Approaches to the Treatment of AIDS
24 Adoptive Immunotherapy with T Cells
25 Cellular Adoptive Immunotherapy with Natural Killer Cells
26 Autologous Tumor Cell Vaccines
27 Allogeneic Cellular Vaccines Against Tumors
28 Neutrophil Transfusions for Treatment of Infections
29 Experimental and Clinical Cellular Immunotherapy in Bone-Marrow Transplantation
30 Donor Lymphocyte Therapy in Bone-Marrow Transplantation
31 Graft-Versus-Leukemia Effect in Bone-Marrow Transplantation
Index


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Cell Therapy: Stem Cell Transplantation, Gene Therapy, and Cellular Immunotherapy





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