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Table of Contents:

List of contributors
Preface
Sect. I Nitric oxide and cytokines - an introduction 1
1 A brief overview of the biology of nitric oxide 3
2 Nitric oxide and immune responses 8
3 Bone biology and pathophysiological mechanisms of bone disease 21
Sect. II Nitric oxide in arthritis 39
4 Nitric oxide and blood flow in arthritis 41
5 Nitric oxide production in human inflammatory arthritides 53
6 Effects of nitric oxide synthase inhibitors in experimental models of arthritis 61
7 Nitric oxide and prostaglandin interactions in acute and chronic inflammation 70
8 The complex influences of reactive oxygen species on rheumatoid erosions and synovitis 81
9 Nitric oxide and cartilage matrix turnover 95
Sect. III Nitric oxide, bone cell function and osteoporosis 103
10 Nitric oxide and osteoblast function 105
11 Nitric oxide as a mediator of cytokine effects on bone 116
12 The osteoclast, bone homeostasis and postmenopausal osteoporosis 122
Sect. IV Nitric oxide and mechanical factors 127
13 Modulation of bone blood flow by nitric oxide 129
14 Fluid shear stress 141
15 Mechanical strain-associated nitric oxide production by bone cells 151
16 The response of bone and bone cells to mechanical stimulation 169
17 Aseptic loosening of total hip prostheses 178
Index 185