Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn

Author: Andrew G. Hadley
Published: March 2002
Publisher: Cambridge University Press
ISBN: 0521781205
Hardcover Book
Number of Pages: 304

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The effective prevention, diagnosis, and management of alloimmune cytopenias has become a team effort involving hematologists, obstetricians, pediatricians, immunologists, laboratory technicians, midwives, and research scientists. This book has been written by experts in their respective fields to bring together the issues of pathogenesis, epidemiology, prevention, diagnosis, and clinical management. This comprehensive but accessible account is extensively cross-referenced to emphasize the links between pathogenesis and clinical sequels, between epidemiology and the rationale for screening programs, and between diagnosis and therapeutic intervention. Written for trainees in obstetric, maternal, and fetal medicine, transfusion medicine, and clinical immunology, this guide offers an overview on the prevention, diagnosis, and management of alloimmune disorders related to pregnancy. Fourteen chapters by obstetricians, pediatricians, immunologists, and research scientists covers the pathogenesis, epidemiology, prevention, diagnosis, and clinical management of the various disorders. Specific chapters discuss blood group antibodies, screening, immune suppression, genotyping, and antenatal and neonatal therapy.

Table of Contents
List of contributors
Preface
Foreword
List of abbreviations
1 Pathophysiology of the alloimmune cytopenias 1
2 Blood group antibodies in haemolytic disease of the fetus and newborn 21
3 Basis and practice of screening for haemolytic disease of the fetus and newborn 41
4 Epidemiology and screening for alloimmune thrombocytopenia 61
5 Principles of antibody-mediated immune suppression and the prevention of maternal RhD alloimmunization 73
6 The clinical application of anti-D prophylaxis 97
7 Fetal genotyping 121
8 Laboratory assays to determine the severity of haemolytic disease of the fetus and newborn 141
9 Assessing the severity of haemolytic disease of the fetus and newborn: clinical aspects 153
10 Antenatal therapy for haemolytic disease of the fetus and newborn 173
11 Neonatal therapy for haemolytic disease of the newborn 203
12 The diagnosis of alloimmune thrombocytopenia 219
13 The Immunological diagnosis of alloimmune neutropenia 235
14 Fetal and neonatal treatment of alloimmune thrombocytopenia 253
Index 279

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