Adaptive Dynamics of Infectious Diseases: In Pursuit of Virulence Management

Author: Ulf Dieckmann
Published: September 2001
Publisher: Cambridge University Press
ISBN: 0521781655
Hardcover Book
Number of Pages: 552

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This monograph takes stock of our current knowledge on the evolutionary ecology of infectious diseases, and sets out the goals for the management of virulent pathogens. Throughout the text, the fundamental concepts and techniques underlying the models are carefully explained in a unique series of integrated boxes. Reports results from a research program on virulence management, sponsored by the International Institute for Applied Systems Analysis (IIASA), that explores the possibility of interfering with or even redirecting the evolution of virulence to achieve desired parasite goals. The 31 papers analyze the implications of host population structure for the evolution of virulence, the competition of pathogens within a host, pathogen-host coevolution, and multilevel selection. The final sections review the long-term effects of vaccines and drugs, and the options and problems of virulence management.

Table of Contents
Contributing Authors
List of Boxes
Notational Standards
1 Introduction 1
2 Alternative Transmission Modes and the Evolution of Virulence 10
3 Wildlife Perspectives on the Evolution of Virulence 26
4 Adaptive Dynamics of Pathogen-Host Interactions 39
5 Dilemmas in Virulence Management 60
6 Variation in Susceptibility: Lessons from an Insect Virus 74
7 Contact Networks and the Evolution of Virulence 85
8 Virulence on the Edge: A Source-Sink Perspective 104
9 Super- and Coinfection: The Two Extremes 124
10 Super- and Coinfection: Filling the Range 138
11 Multiple Infection and Its Consequences for Virulence Management 150
12 Kin-selection Models as Evolutionary Explanations of Malaria 165
13 Coevolution of Virus and Host Cell-death Signals 183
14 Biogeographical Perspectives on Arms Races 197
15 Major Histocompatibility Complex: Polymorphism from Coevolution 210
16 Virulence Management and Disease Resistance in Diploid Hosts 222
17 Coevolution in Gene-for-gene Systems 233
18 Implications of Sexual Selection for Virulence Management 248
19 Molecular Phylogenies and Virulence Evolution 262
20 Weakened from Within: Intragenomic Conflict and Virulence 280
21 Ecology and Evolution of Chestnut Blight Fungus 286
22 Evolution of Exploitation and Defense in Tritrophic Interactions 297
23 Managing Antibiotic Resistance: What Models Tell Us? 326
24 Evolution of Vaccine-resistant Strains of Infectious Agents 339
25 Pathogen Evolution: The Case of Malaria 347
26 Vaccination and Serotype Replacement 362
27 Taking Stock: Relating Theory to Experiment 379
28 Virulence Management in Humans 399
29 Virulence Management in Wildlife Populations 413
30 Virulence Management in Veterinary Epidemiology 425
31 Virulence Management in Plant-Pathogen Interactions 436
32 Virulence Management in Biocontrol Agents 448
33 Epilogue 460
References 465
Index 515

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