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Table of Contents:

List of contributors
Foreword
Preface
Pt. I Epidemiology, Pathophysiology and Pathogenesis of Fetal and Neonatal Brain Injury
1 Perinatal asphyxia: an overview 3
2 Mechanisms of brain damage in animal models of hypoxia-ischemia in newborns 30
3 Cellular and molecular biology of perinatal hypoxic-ischemic brain damage 58
4 Fetal responses to asphyxia 83
5 Congenital malformations of the brain 111
6 Prematurity and complications of labor and delivery 129
7 Intrauterine growth retardation (restriction) 145
8 Hemorrhagic lesions of the central nervous system 175
Pt. II Pregnancy, Labor, and Delivery Complications Causing Brain Injury
9 Maternal diseases that affect fetal development 191
10 Antepartum evaluation of fetal well-being 212
11 Intrapartum evaluation of the fetus 226
12 Obstetrical conditions and practices that affect the fetus and newborn 244
13 Fetal and neonatal injury as a consequence of maternal substance abuse 274
14 Chorioamnionitis and its possible relation to subsequent cerebral palsy 303
15 Bacterial sepsis in the neonate 314
16 Neonatal bacterial meningitis 333
17 Neurological sequelae of congenital perinatal infection 355
18 Perinatal human immunodeficiency virus infection 377
19 Inborn errors of metabolism with features of hypoxic-ischemic encephalopathy 392
Pt. III Diagnosis of the Infant with Asphyxia
20 Clinical manifestations of hypoxic-ischemic encephalopathy 411
21 The use of the EEG in assessing acute and chronic brain damage in the newborn 425
22 Structural and functional imaging of hypoxic-ischemic injury (HII) in the fetal and neonatal brain 446
23 Near-infrared spectroscopy and imaging 490
24 Placental pathology and the etiology of fetal and neonatal brain injury 519
25 Correlations of clinical, laboratory, imaging and placental findings as to the timing of asphyxial events 540
Pt. IV Specific Conditions Associated with Fetal and Neonatal Brain Injury
26 Hypoglycemia in the neonate 553
27 Hyperbilirubinemia and kernicterus 571
28 Polycythemia 578
29 Hydrops fetalis 586
30 Acidosis/alkalosis 593
31 Meconium staining and the meconium aspiration syndrome 612
32 Persistent pulmonary hypertension of the newborn 636
33 Pediatric cardiac surgery: relevance to fetal and neonatal brain injury 663
Pt. V Management of the Depressed or Neurologically Dysfunctional Neonate
34 Neonatal resuscitation: immediate management 673
35 Extended management 692
36 Neuroprotective mechanisms after hypoxic-ischemic injury 715
37 Neonatal seizures: an expression of fetal or neonatal brain disorders 735
38 Improving performance, reducing error, and minimizing risk in the delivery room 785
39 Nutritional support of the asphyxiated infant 791
Pt. VI Assessing the Outcome of the Asphyxiated Infant
40 Assessment of preterm infants' neurobehavioral functioning: reliability, validity, normative data, and prediction to age two 817
41 Long-term follow-up of term infants with perinatal asphyxia 829
42 Appropriateness of intensive care application 859
43 Medicolegal issues in perinatal brain injury 873
Index 887