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List of Contributors
Foreword
Preface to the Third Edition
Preface to the First Edition
1 Gene Structure, Recombinant DNA Technology and its Application in Paediatric Endocrinology 1
2 Applications of Molecular Genetics in the Study of Clinical Disorders 23
3 Physiology of Sexual Determination and Differentiation 41
4 The Clinical Management of Ambiguous Genitalia 53
5 Growth Factors and Prenatal Development: Recent Lessons from Molecular Biology 69
6 Normal Growth and its Endocrine Control 85
7 The Insulin-like Growth Factors 107
8 Signalling Mechanisms and Hormone Pulsatility 123
9 Short Stature 136
10 The Management of Short Stature 173
11 Growth-hormone-resistant States 187
12 Tall Stature 195
13 The Fat Child 210
14 The Physiology Puberty 234
15 Disorders of Puberty 253
16 Gynaecology 274
17 Reproductive Endocrinology - The Ovary 288
18 Reproductive Endocrinology - The Testis 298
19 Anatomy and Physiology of the Hypothalamopituitary Axis 310
20 Neuroradiology 320
21 The Neurosurgical Approach to Hypothalamohypophyseal Tumours 346
22 Thyroid, Adrenal and Pancreatic Surgery 359
23 Gynaecological Endocrine Surgery 364
24 Endocrine-related Urological Surgery 371
25 Growth and Endocrine Sequelae Following the Treatment of Childhood Cancer 383
26 The Thyroid Gland 397
27 The Adrenal Cortex 434
28 Adrenal Steroid Deficiency States 453
29 Adrenal Steroid Excess 499
30 Congenital Adrenal Hyperplasia 536
31 Salt and Water Balance: Sodium-losing States and Endocrine Hypertension 558
32 The Neurohypophysis and Water Regulation 580
33 Pathophysiology of Diabetes Mellitus 616
34 The Management of Diabetes Mellitus 654
35 Hypoglycaemia 677
36 Lipid Disorders 694
37 Endocrine Control of Calcium and Bone Metabolism 713
38 Disorders of Calcium and Bone Metabolism 735
39 Laboratory Approach to the Child with Suspected Disorders of Calcium and Bone Metabolism 779
40 Tests and Normal Values in Paediatric Endocrinology 782
Index 799