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Drs. Arroyo and Schrier have gathered a group of renowned experts to address the need for a current and comprehensive examination of the physiologic and pathophysiologic relationships between liver disease and the kidney.

Table of Contents:

Contributors
Preface
Pt. I Clinical Aspects of Ascites and Renal Dysfunction in Liver Diseases
1 Historical Notes on Ascites in Cirrhosis 3
2 Characteristics of Ascites 14
3 Clinical Disorders of Renal Function in Cirrhosis with Ascites 36
4 Clinical Disorders of Renal Function in Acute Liver Failure 63
5 Renal Dysfunction and Postoperative Renal Failure in Obstructive Jaundice 79
6 Spontaneous Bacterial Peritonitis 99
7 Etiology, Diagnosis, and Management of Noncirrhotic Ascites 116
Pt. II Regulation of Extracellular Fluid Volume and Renal and Splanchnic Circulation
8 Extracellular Fluid Volume Homeostasis 129
9 Physiology of the Renal Circulation 143
10 Physiology of the Gastrointestinal and Liver Circulation 161
Pt. III Factors Involved in the Pathogenesis of Renal Dysfunction and Ascites in Cirrhosis
11 The Renin-Angiotensin-Aldosterone System in Cirrhosis 175
12 The Sympathetic Nervous System in Cirrhosis 198
13 Arginine Vasopressin in Cirrhosis 220
14 Atrial Natriuretic Peptide and Other Natriuretic Factors in Cirrhosis 231
15 Arachidonic Acid Metabolites and the Kidney in Cirrhosis 249
16 Nitric Oxide and Systemic and Renal Hemodynamic Disturbances in Cirrhosis 273
17 Endothelin and Systemic, Renal, and Hepatic Hemodynamic Disturbances in Cirrhosis 291
Pt. IV Systemic and Splanchnic Hemodynamic Abnormalities in Cirrhosis
18 The Systemic Circulation in Cirrhosis 307
19 The Splanchnic Circulation in Cirrhosis 330
20 Alterations of Hepatic and Splanchnic Microvascular Exchange in Cirrhosis: Local Factors in the Formation of Ascites 351
Pt. V Experimental Models of Portal Hypertension and Cirrhosis with Ascites
21 Experimental Models in the Investigation of Portal Hypertension 365
22 Renal Dysfunction and Ascites in Carbon Tetrachloride-Induced Cirrhosis in Rats 379
23 Bacterial Infection of the Ascitic Fluid in Rats with Carbon Tetrachloride-Induced Cirrhosis 397
Pt. VI Pathogenesis of Ascites and Renal and Circulatory Dysfunction in Cirrhosis
24 The Arterial Vasodilation Hypothesis of Ascites Formation in Cirrhosis 411
Pt. VII Therapy of Ascites and Renal Dysfunction in Cirrhosis
25 Prognosis of Cirrhosis with Ascites 431
26 Medical Treatment of Ascites in Cirrhosis 442
27 Treatment of Ascites by Paracentesis 463
28 Treatment of Refractory Ascites in Cirrhosis 480
29 Treatment of Hepatorenal Syndrome in Cirrhosis 492
30 Drug-Induced Renal Failure in Cirrhosis 511
31 Liver Transplantation in Cirrhotic Patients with Ascites 522
32 Treatment and Prophylaxis of Spontaneous Bacterial Peritonitis 538
Index 551