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Contributing Authors
Preface to the First Edition
Preface
Acknowledgments
1 The hematopoietic system and hematopoiesis 1
2 The immune system: structure and function 43
3 Immunophenotypic markers useful in the diagnosis and classification of hematopoietic neoplasms 93
4 Immunohistochemical analysis of lymphoid tissue 227
5 Flow cytometric analysis of hematologic specimens 255
6 Normal histology and immunoarchitecture of the lymphohematopoietic system 271
7 Antigen receptor genes: structure, function, and genetic analysis of their rearrangements 307
8 Protooncogenes and tumor suppressor genes in hematopoietic malignancies 329
9 Application of molecular genetics to the diagnosis and classification of malignant lymphoma 365
10 Role of cytogenetics in the diagnosis and classification of hematopoietic neoplasms 391
11 Organization and operation of a hematopathology laboratory 419
12 Technical factors in the preparation and evaluation of lymph node biopsies 467
13 The role of fine needle aspiration biopsy in the diagnosis and management of hematopoietic neoplasms 483
14 Diagnostic significance of morphologic patterns of lymphoid proliferations in lymph nodes 507
15 The reactive lymphadenopathies 537
16 Atypical lymphoproliferative disorders 569
17 Hodgkin's disease: histopathology and differential diagnosis 623
18 Hodgkin's diseas: Cell of origin, immunobiology, and pathogenesis 667
19 Classification of non-Hodgkin's lymphomas 691
20 Clinical relevance of the revised European-American classification of non-Hodgkin's lymphomas 755
21 Small lymphocytic lymphoma 773
22 Mantle cell lymphoma 789
23 Nodal marginal zone B-cell lymphomas 805
24 Follicular lymphoma 823
25 Diffuse large cell lymphomas 855
26 Lymphoblastic lymphoma 915
27 Burkitt's lymphoma 953
28 Lymphadenopathy and the lymphoid neoplasms associated with the acquired immune deficiency syndrome 987
29 Peripheral T-Cell lymphomas 1091
30 Nonhematopoietic elements in lymph nodes 1127
31 Extranodal lymphoid proliferations: General principles 1165
32 Benign and malignant cutaneous lymphoproliferative disorders including mycosis fungoides 1183
33 Gastrointestinal lymphomas and lymphoid hyperplasias 1235
34 Pulmonary lymphomas and lymphoid hyperplasias 1263
35 Malignant lymphomas and lymphoid hyperplasias that occur in the ocular adnexa (orbit, conjunctiva, and eyelids) 1303
36 Waldeyer's ring, sinonasal region, salivary gland, thyroid gland, central nervous system, and other extranodal lymphomas and lymphoid hyperplasias 1351
37 Bone marrow Specimen processing 1391
38 Cytochemical, histochemical, and immunohistochemical analysis of the bone marrow 1407
39 Bone marrow manifestations of Hodgkin's and non-Hodgkin's lymphomas and lymphoma-like disorders 1447
40 B-Cell chronic lymphocytic and prolymphocytic leukemia 1505
41 Hairy cell leukemia and related disorders 1531
42 B-cell immunoproliferative disorders, including multiple myeloma and amyloidosis 1557
43 Leukemias of mature T cells 1589
44 Adult T-cell leukemia/lymphoma 1603
45 Application of molecular genetics to the diagnosis and classification of acute Leukemia 1617
46 Acute lymphoblastic leukemia 1643
47 Acute myeloid leukemia 1667
48 Myelodysplastic syndromes 1717
49 Chronic myelogenous leukemia and the chronic myeloproliferative diseases 1745
50 Interpretation of postchemotherapy and posttransplantation bone marrow specimens 1791
51 Histiocytic and dendritic cell proliferations 1815
52 Mast cell disease 1847
53 Histopathologic manifestations of lymphoproliferative and myeloproliferative disorders involving the spleen 1881
Subject index 1915