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Sect. I Methodology 1
1 Contributions of Basic Research, Observational Studies, and Randomized Trials 3
2 Methodology of Randomized Trials 9
3 Comparative Features of Primordial, Primary, and Secondary Prevention Trials 17
4 Large-Scale Randomized Trials 24
5 Principles of Data and Safety Monitoring Boards in Randomized Trials 31
6 Meta-Analysis of Randomized Trials 43
Sect. II Treatment Trials 53
7 Aspirin and Heparin 55
8 Thrombolytic Therapy 65
9 Beta Blockers 76
10 Angiotensin-Converting Enzyme Inhibitors 95
11 Calcium Channel Blockers 106
12 Magnesium 119
13 Nitrates 131
14 Direct Thrombin Inhibitors 145
15 Platelet Glycoprotein IIb/IIIa Receptor Inhibitors 166
16 Primary Angioplasty, Rescue Angioplasty, and New Devices 185
17 Lipid-Lowering Therapy 199
18 Antiarrhythmic Drug Therapy 217
19 Antiarrhythmic Drug Therapy in Supraventricular Tachycardia 231
20 Antithrombotic and Anticoagulant Therapy 245
21 Anticoagulant and Antiplatelet Drug Therapy in Atrial Fibrillation 257
22 Angioplasty and Bypass Surgery 267
23 Exercise 278
24 Congestive Heart Failure 296
25 Psychosocial Factors 315
Sect. III Prevention Trials 325
26 Cholesterol Reduction 327
27 Blood Pressure Reduction 341
28 Smoking Cessation 361
29 Exercise and Weight Loss 375
30 Aspirin 392
31 Postmenopausal Hormone Replacement Therapy 399
32 Antioxidant Vitamins 415
33 Dietary Factors 423
34 Multiple Risk Factor Intervention Trials 432
35 Prevention Strategies: From the Office to the Community 447
Index 461