Hematology in Infancy and Childhood

Author: David J. Magee
Published: May 2003
Publisher: Elsevier Science
ISBN: 0721693172
Hardcover Book
Number of Pages: 2060

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& Basing their work on an approach that assumes diagnosis and treatment should be based more on basic pathophysiology than description and association, the editors (affiliated with the Dana-Farber Cancer Institute, the U. of Michigan, the Howard Hughes Medical Institute, and Harvard Medical School) present the new edition of a two-volume textbook that, for the most part, provides chapters on the major hematological diseases that include discussions of their fundamental bases. Chapters that don't fall into the above category include discussions of basic blood biology without reference to disease or look at widespread treatment techniques, such as transfusion medicine. Suggested for initial purchase by Brandon-Hill.

Table of Contents:

I History 1
1 Pediatric Hematology in Historical Perspective 3
II Neonatal Hematology 17
2 The Neonatal Erythrocyte and Its Disorders 19
3 Immune Hemolytic Disease 56
4 Disorders of Bilirubin Metabolism 86
5 Developmental Hemostasis: Relevance to Newborns and Infants 121
III Bone Marrow Failure 169
6 The Anatomy and Physiology of Hematopoiesis 171
7 Acquired Aplastic Anemia 256
8 Inherited Bone Marrow Failure Syndromes 280
9 Principles of Bone Marrow and Stem Cell Transplantation 366
IV Disorders of Erythrocyte Production 407
10 A Diagnostic Approach to the Anemic Patient 409
11 Megaloblastic Anemia 419
12 Disorders of Iron Metabolism and Sideroblastic Anemia 456
13 The Porphyrias 498
V Hemolytic Anemias 519
14 Autoimmune Hemolytic Anemia 521
15 Disorders of the Erythrocyte Membrane 560
16 Pyruvate Kinase Deficiency and Disorders of Glycolysis 685
17 Glucose-6-Phosphate Dehydrogenase Deficiency and Hemolytic Anemia 721
VI Disorders of Hemoglobin 743
18 Hemoglobins: Normal and Abnormal 745
19 Sickle Cell Disease 790
20 The Thalassemias 842
VII The Phagocyte System 921
21 The Phagocyte System of Disorders of Granulopoiesis and Granulocyte Function 923
VIII The Immune System 1011
22 Cell-Mediated and Humoral Immunity and the Regulation of Immune Responses 1013
23 Primary Immunodeficiency Diseases 1043
IX Oncology 1079
24 Epidemiology of Leukemia in Childhood 1081
25 Chromosomal Abnormalities in Childhood Hematologic Malignant Disease 1101
26 Acute Lymphoblastic Leukemia 1135
27 Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease in Children 1167
28 Acute Leukemia in Infants 1210
29 The Molecular Basis of Hematologic Malignancy 1219
30 Minimal Residual Leukemia 1259
31 Pharmacology of Antineoplastic Agents and Multidrug Resistance 1274
32 Cell, Cytokine, Monoclonal Antibody, and Gene Therapy 1307
33 The Lymphomas and Lymphadenopathy 1333
34 Lymphohistiocytic Disorders 1375
X Storage Diseases 1397
35 Storage Diseases of the Reticuloendothelial System 1399
XI Hemostasis 1455
36 Blood Platelets and the Vessel Wall 1457
37 Blood Coagulation 1475
38 The Molecular Basis of Fibrinolysis 1497
39 Clinical and Laboratory Approach to the Patient with Bleeding 1515
40 Inherited Platelet Disorders 1527
41 Hemophilia and von Willebrand Disease 1547
42 Rare Hereditary Coagulation Factor Abnormalities 1577
43 Inherited Disorders of Thrombosis and Fibrinolysis 1583
44 Acquired Platelet Defects 1597
45 Acquired Disorders of Hemostasis 1631
XII Supportive Therapy 1669
46 Psychologic Aspects of Leukemia and Hematologic Disorders 1671
47 Infectious Complications in Children with Hematologic Disorders 1684
48 Transfusion Medicine 1709
XIII Hematologic Manifestations of Systemic Diseases 1757
49 Hematologic Manifestations of Systemic Diseases 1759
50 Hematologic Manifestations of Systemic Diseases in Children of the Developing World 1810
App Reference Values in Early Childhood 1835
Index

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